Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANXA2 | P07355 | 9/20 | 0.53 |
| ▸ | S100A10 | P60903 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2234748 | 0.78 | ANXA2 (0.44) | ANXA2S100A10ALDH1A1USP2GFER | |
| SCHEMBL2232974 | 0.70 | ANXA2 (0.65) | ANXA2S100A10ALDH1A1MALT1 | |
| SCHEMBL2234193 | 0.70 | ANXA2 (0.67) | ANXA2S100A10ALDH1A1MALT1USP2 | |
| SCHEMBL2235370 | 0.70 | ANXA2 (0.53) | ANXA2S100A10ALDH1A1MALT1 | |
| SCHEMBL26490140 | 0.68 | ALDH1A1 (0.70) | ALDH1A1CNR1CNR2SMN1; SMN2NPSR1 | |
| SCHEMBL2233839 | 0.68 | ANXA2 (0.68) | ANXA2S100A10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2303389 | 0.68 | ANXA2 (0.66) | ANXA2S100A10ALDH1A1MALT1TP53 | |
| SCHEMBL12668752 | 0.67 | PPARG (0.57) | ALDH1A1POLBMAPT | |
| SCHEMBL2232358 | 0.67 | CCR1 (0.59) | ANXA2S100A10ALDH1A1TP53LMNA | |
| SCHEMBL2234313 | 0.67 | ANXA2 (0.45) | ANXA2S100A10ALDH1A1POLBMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092505-A1 | S100 PROTEIN BINDING INTERACTION INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-08-04 | — | — | WO | claimed |
| WO-2011092505-A1 | S100 PROTEIN BINDING INTERACTION INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-08-04 | — | — | WO | disclosed |