Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22347663 | 0.68 | HSD11B1 (0.39) | HSD11B1OPRK1DGAT1NPC1RAB9A | |
| SCHEMBL19189061 | 0.68 | SLC6A12 (0.34) | — | |
| SCHEMBL25074421 | 0.67 | EPHX1 (0.33) | — | |
| SCHEMBL23329861 | 0.67 | CYP4F2 (0.33) | — | |
| SCHEMBL22353633 | 0.66 | DPP4 (0.30) | — | |
| SCHEMBL9951753 | 0.65 | NPSR1 (0.38) | — | |
| SCHEMBL14968320 | 0.64 | HSD11B1 (0.35) | HSD11B1OPRK1DGAT1NPC1RAB9A | |
| SCHEMBL22824391 | 0.63 | KCNA3 (0.31) | — | |
| SCHEMBL13769236 | 0.62 | LMNA (0.34) | — | |
| SCHEMBL1282303 | 0.61 | OPRK1 (0.38) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020168143-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-20 | — | — | WO | disclosed |