SCHEMBL223661

SCHEMBL223661

CCCCCCCCc1ccc2c(c1)Sc1ccccc1N2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOX1 Q9Y5S8 9/20 0.50
GAA P10253 4/20 0.50
MAPT P10636 4/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
SNCA P37840 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
MAPK1 P28482 2/20 0.50
BCHE P06276 2/20 0.50
ACHE P22303 2/20 0.50
ALOX15 P16050 2/20 0.50
LMNA P02545 1/20 0.50
HTT P42858 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CYP1A2 P05177 1/20 0.50
POLB P06746 1/20 0.50
CYP3A4 P08684 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
ALOX12 P18054 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8150371 1.00 NOX1 (0.50) NOX1GAAMAPTMEN1KMT2A
SCHEMBL8156091 1.00 NOX1 (0.50) NOX1GAAMAPTMEN1KMT2A
SCHEMBL8147738 0.94 NOX1 (0.53) NOX1GAAMAPTMEN1KMT2A
SCHEMBL7765522 0.92 PTGS2 (0.46) SNCAACHELMNACYP3A4ADORA3
SCHEMBL29640428 0.92 PTGS2 (0.46) SNCAACHELMNACYP3A4ADORA3
SCHEMBL225844 0.92 PTGS2 (0.46) SNCAACHELMNACYP3A4ADORA3
SCHEMBL29399785 0.92 PTGS2 (0.46) SNCAACHELMNACYP3A4ADORA3
SCHEMBL8142919 0.92 PTGS2 (0.46) SNCAACHELMNACYP3A4ADORA3
SCHEMBL7528258 0.91 NOX1 (0.50) NOX1GAAMAPTMEN1KMT2A
SCHEMBL17999681 0.91 NOX1 (0.50) NOX1GAAMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4363745-A STERICALLY HINDERED PHENOL, BIS(A,A-DIMETHYLBENZYL) DIPHENYLAMINE AND A PHENOTHIAZINE COMPOUND STABILIZERS THE DOW CHEMICAL COMPANY (US) 1982-12-14 US claimed
US-4275173-A SYNERGISTIC COMBINATION OF A STERICALLY HINDERED PHENOL AND 4,4*-BIS/A,A-DIMETHYLBENZYL/DIPHENYL AMINE AND A PHENOTHIAZINE PROVIDE OXIDATION RESISTANCE THE DOW CHEMICAL COMPANY (US) 1981-06-23 US claimed
US-4265783-A SYNERGISTIC COMBINATION OF STERIC HINDERED PHENOL, 4,4*-BIS/A,A-DIMETHYL BENZYL/DIPHENYLAMINE AND A PHENOTHIAZINE THE DOW CHEMICAL COMPANY (US) 1981-05-05 US claimed
US-4010211-A 2,6-DI-TERT-BUTYL-P-CRESOL, DISUBSTITUTED DIPHENYLAMINE, PHENOTHIAZINE COMPOUND OLIN CORPORATION (US) 1977-03-01 US claimed
US-20260103652-A1 MACROMOLECULAR CORROSION (McIn) INHIBITORS: STRUCTURES, METHODS OF MAKING AND USING THE SAME POLNOX CORP (US) 2026-04-16 US disclosed
US-12492352-B2 Macromolecular corrosion (MCIN) inhibitors: structures, methods of making and using the same POLNOX CORPORATION (US) 2025-12-09 US disclosed
US-20230159841-A1 MACROMOLECULAR CORROSION (MCIN) INHIBITORS: STRUCTURES, METHODS OF MAKING AND USING THE SAME POLNOX CORPORATION 2023-05-25 US disclosed
US-11578285-B2 Macromolecular corrosion (McIn) inhibitors: structures, methods of making and using the same POLNOX CORPORATION (US) 2023-02-14 US disclosed
EP-3071544-B1 MACROMOLECULAR ANTIOXIDANTS BASED ON DUAL TYPE MOIETY PER MOLECULE: STRUCTURES METHODS OF MAKING AND USING THE SAME POLNOX CORP (US) 2022-07-06 EP disclosed
US-11060027-B2 Macromolecular antioxidants based on dual type moiety per molecule: structures, methods of making and using the same POLNOX CORPORATION (US) 2021-07-13 US disclosed
US-20210130722-A1 MACROMOLECULAR CORROSION (MCIN) INHIBITORS: STRUCTURES, METHODS OF MAKING AND USING THE SAME POLNOX CORPORATION 2021-05-06 US disclosed
US-20200392406-A1 MACROMOLECULAR ANTIOXIDANTS BASED ON DUAL TYPE MOIETY PER MOLECULE: STRUCTURES, METHODS OF MAKING AND USING THE SAME POLNOX CORPORATION 2020-12-17 US disclosed
US-20120004150-A1 Lubricant Oil Compositions POLNOX CORPORATION 2012-01-05 US disclosed
EP-1963468-A1 LUBRICANT OIL COMPOSITIONS Polnox Corporation (US) 2008-09-03 EP disclosed
US-20070161522-A1 Lubricant oil compositions POLNOX CORPORATION 2007-07-12 US disclosed
WO-2007064843-A1 LUBRICANT OIL COMPOSITIONS POLNOX CORPORATION (US) 2007-06-07 WO disclosed
US-4363745-A STERICALLY HINDERED PHENOL, BIS(A,A-DIMETHYLBENZYL) DIPHENYLAMINE AND A PHENOTHIAZINE COMPOUND STABILIZERS THE DOW CHEMICAL COMPANY (US) 1982-12-14 US disclosed
US-4275173-A SYNERGISTIC COMBINATION OF A STERICALLY HINDERED PHENOL AND 4,4*-BIS/A,A-DIMETHYLBENZYL/DIPHENYL AMINE AND A PHENOTHIAZINE PROVIDE OXIDATION RESISTANCE THE DOW CHEMICAL COMPANY (US) 1981-06-23 US disclosed
US-4265783-A SYNERGISTIC COMBINATION OF STERIC HINDERED PHENOL, 4,4*-BIS/A,A-DIMETHYL BENZYL/DIPHENYLAMINE AND A PHENOTHIAZINE THE DOW CHEMICAL COMPANY (US) 1981-05-05 US disclosed
US-4010211-A 2,6-DI-TERT-BUTYL-P-CRESOL, DISUBSTITUTED DIPHENYLAMINE, PHENOTHIAZINE COMPOUND OLIN CORPORATION (US) 1977-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11060027-B2 Macromolecular antioxidants based on dual type moiety per molecule: structures, methods of making and using the same LPO, GPX4, DUOX2 NOX1 180/4885GAA 1034/4885MAPT 2287/4885
US-11578285-B2 Macromolecular corrosion (McIn) inhibitors: structures, methods of making and using the same MB, NCLN, CPN1 NOX1 606/4885GAA 61/4885MAPT 2540/4885
US-20210130722-A1 MACROMOLECULAR CORROSION (MCIN) INHIBITORS: STRUCTURES, METHODS OF MAKING AND USING THE SAME MB, NCLN, CPN1 NOX1 606/4885GAA 61/4885MAPT 2540/4885
US-20200392406-A1 MACROMOLECULAR ANTIOXIDANTS BASED ON DUAL TYPE MOIETY PER MOLECULE: STRUCTURES, METHODS OF MAKING AND USING THE SAME LPO, GPX4, DUOX2 NOX1 180/4885GAA 1034/4885MAPT 2287/4885
US-12492352-B2 Macromolecular corrosion (MCIN) inhibitors: structures, methods of making and using the same MB, NCLN, CPN1 NOX1 606/4885GAA 61/4885MAPT 2540/4885
US-20260103652-A1 MACROMOLECULAR CORROSION (McIn) INHIBITORS: STRUCTURES, METHODS OF MAKING AND USING THE SAME MPO, CYC1, CBR1 NOX1 9/4885GAA 624/4885MAPT 4131/4885
US-20230159841-A1 MACROMOLECULAR CORROSION (MCIN) INHIBITORS: STRUCTURES, METHODS OF MAKING AND USING THE SAME MB, NCLN, CPN1 NOX1 606/4885GAA 61/4885MAPT 2540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.