Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.55 |
| ▸ | ESRRG | P62508 | 3/20 | 0.52 |
| ▸ | ESRRB | O95718 | 1/20 | 0.51 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15037126 | 1.00 | LNPEP (0.55) | LNPEPESRRGESRRBLY96CTSS | |
| SCHEMBL15096411 | 0.90 | MAPT (0.49) | LNPEPLY96POLBMAPTTDP1 | |
| SCHEMBL27616693 | 0.89 | CTSL (0.60) | LNPEPLY96CTSSCTSKPOLB | |
| SCHEMBL19485398 | 0.89 | MAPT (0.59) | POLBMAPTTDP1CTSLROCK2 | |
| SCHEMBL7703695 | 0.88 | LNPEP (0.53) | LNPEPLY96CTSSCTSKCA1 | |
| SCHEMBL28217499 | 0.86 | LNPEP (0.58) | LNPEPLY96CTSSCTSKCA1 | |
| SCHEMBL28217498 | 0.86 | LNPEP (0.58) | LNPEPLY96CTSSCTSKCA1 | |
| SCHEMBL15019672 | 0.85 | CA2 (0.65) | LNPEPESRRGESRRBCA1CA2 | |
| SCHEMBL28535866 | 0.85 | CA2 (0.65) | LNPEPESRRGESRRBCA1CA2 | |
| SCHEMBL28294749 | 0.84 | MAPT (0.50) | POLBMAPTTDP1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074820-B | GLP-1 receptor modulators | 赛尔基因第二国际有限公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-112457301-A | Novel GLP-1 receptor modulators | 赛尔基因第二国际有限公司 | 2021-03-09 | — | — | CN | disclosed |
| EP-3008056-B1 | NOVEL GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-12-09 | — | — | EP | disclosed |
| EP-2791112-B1 | CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES | CELGENE INT II SÀRL (CH) | 2020-09-23 | — | — | EP | disclosed |
| EP-3230276-B1 | GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-09-02 | — | — | EP | disclosed |