SCHEMBL22411205

SCHEMBL22411205

CC(C)(C)c1cc2cc3ccccc3cc2c(Br)c1C(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NQO1 P15559 1/20 0.33
▸ CYP2A6 P11509 1/20 0.32
▸ HDAC1 Q13547 2/20 0.32
▸ HDAC7 Q8WUI4 2/20 0.32
▸ HDAC8 Q9BY41 2/20 0.32
▸ HDAC6 Q9UBN7 2/20 0.32
▸ HDAC3 O15379 1/20 0.32
▸ HDAC4 P56524 1/20 0.32
▸ HDAC2 Q92769 1/20 0.32
▸ HDAC10 Q969S8 1/20 0.32
▸ HDAC11 Q96DB2 1/20 0.32
▸ HDAC9 Q9UKV0 1/20 0.32
▸ HDAC5 Q9UQL6 1/20 0.32
▸ ALDH1A1 P00352 2/20 0.31
▸ TDP1 Q9NUW8 2/20 0.31
▸ TSHR P16473 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ ALOX15 P16050 1/20 0.31
▸ CASP1 P29466 1/20 0.31
▸ CASP7 P55210 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11377784 0.83 NQO1 (0.36) NQO1CYP2A6HDAC1HDAC7HDAC8
SCHEMBL27830907 0.80 ALDH1A1 (0.39) NQO1CYP2A6HDAC1HDAC7HDAC8
SCHEMBL25212109 0.76 ALDH1A1 (0.34) NQO1CYP2A6HDAC1HDAC7HDAC8
SCHEMBL9651812 0.75 CA2 (0.41) ALDH1A1TDP1TSHRCYP3A4ALOX15
SCHEMBL5010176 0.75 NQO1 (0.39) NQO1CYP2A6HDAC1HDAC7HDAC8
SCHEMBL6135773 0.75 ESR1 (0.39) NQO1ALDH1A1TSHRHSD17B10
SCHEMBL3420318 0.74 ALDH1A1 (0.40) NQO1CYP2A6HDAC1HDAC7HDAC8
SCHEMBL354097 0.74 ALDH1A1 (0.42) NQO1CYP2A6ALDH1A1TDP1TSHR
SCHEMBL10496284 0.73 ALDH1A1 (0.33) CYP2A6ALDH1A1HIF1AHSD17B10
SCHEMBL27686228 0.73 ALDH1A1 (0.39) NQO1CYP2A6HDAC1HDAC7HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12297311-B2 Biaryl hydroxythiophene group IV transition metal polymerization with chain transfer capability DOW GLOBAL TECHNOLOGIES LLC (US) 2025-05-13 — — US disclosed
US-20250051495-A1 SUPPORTED CATALYST SYSTEMS CONTAINING A SILOCON BRIDGED, ANTHRACENYL SUBSTITUTED BIS-BIPHENYL-PHENOXY ORGANOMETALLIC COMPOUND FOR MAKING POLYETHYLENE AND POLYETHYLENE COPOLYMER RESINS IN A GAS PHASE POLYMERIZATION REACTOR DOW GLOBAL TECHNOLOGIES LLC (US) 2025-02-13 — — US disclosed
US-20250034292-A1 SUPPORTED CATALYST SYSTEMS CONTAINING A GERMANIUM BRIDGED, ANTHRACENYL SUBSTITUTED BIS-BIPHENYL-PHENOXY ORGANOMETALLIC COMPOUND FOR MAKING POLYETHYLENE AND POLYETHYLENE COPOLYMER RESINS IN A GAS PHASE POLYMERIZATION REACTOR DOW GLOBAL TECHNOLOGIES LLC (US) 2025-01-30 — — US disclosed
US-20250011478-A1 SUPPORTED CATALYST SYSTEMS CONTAINING A CARBON BRIDGED, ANTHRACENYL SUBSTITUTED BIS-BIPHENYL-PHENOXY ORGANOMETALLIC COMPOUND FOR MAKING POLYETHYLENE AND POLYETHYLENE COPOLYMER RESINS IN A GAS PHASE POLYMERIZATION REACTOR DOW GLOBAL TECHNOLOGIES LLC (US) 2025-01-09 — — US disclosed
US-12122862-B2 Biaryl hydroxythiophene group IV transition metal polymerization catalysts with chain transfer capability DOW GLOBAL TECHNOLOGIES LLC (US) 2024-10-22 — — US disclosed
EP-4437012-A1 SUPPORTED CATALYST SYSTEMS CONTAINING A CARBON BRIDGED, ANTHRACENYL SUBSTITUTED BIS-BIPHENYL-PHENOXY ORGANOMETALLIC COMPOUND FOR MAKING POLYETHYLENE AND POLY ETHYLENE COPOLYMER RESINS IN A GAS PHASE POLYMERIZATION REACTOR Dow Global Technologies LLC (US) 2024-10-02 — — EP disclosed
EP-4437011-A1 SUPPORTED CATALYST SYSTEMS CONTAINING A GERMANIUM BRIDGED, ANTHRACENYL SUBSTITUTED BIS-BIPHENYL-PHENOXY ORGANOMETALLIC COMPOUND FOR MAKING POLYETHYLENE AND POLYETHYLENE COPOLYMER RESINS IN A GAS PHASE POLYMERIZATION REACTOR Dow Global Technologies LLC (US) 2024-10-02 — — EP disclosed
EP-4437013-A1 SUPPORTED CATALYST SYSTEMS CONTAINING A SILOCON BRIDGED, ANTHRACENYL SUBSTITUTED BIS-BIPHENYL-PHENOXY ORGANOMETALLIC COMPOUND FOR MAKING POLYETHYLENE AND POLYETHYLENE COPOLYMER RESINS IN A GAS PHASE POLYMERIZATION REACTOR Dow Global Technologies LLC (US) 2024-10-02 — — EP disclosed
US-12104002-B2 Monobidentate aminopyridine group IV transition metal olefin copolymerization catalysts with ultra-high molecular weight capability and ultra-low comonomer incorporation DOW GLOBAL TECHNOLOGIES LLC (US) 2024-10-01 — — US disclosed
CN-118451111-A Supported catalyst system containing silicon-bridged, anthracenyl-substituted bis-biphenyl-phenoxy organometallic compounds for preparing polyethylene and polyethylene copolymer resins in a gas phase polymerization reactor 陶氏环球技术有限责任公司 2024-08-06 — — CN disclosed
US-20220169756-A1 BIARYL HYDROXYTHIOPHENE GROUP IV TRANSITION METAL POLYMERIZATION WITH CHAIN TRANSFER CAPABILITY DOW GLOBAL TECHNOLOGIES LLC (US) 2022-06-02 — — US disclosed
US-20220162354-A1 MONOBIDENTATE AMINOPYRIDINE GROUP IV TRANSITION METAL OLEFIN COPOLYMERIZATION CATALYSTS WITH ULTRA-HIGH MOLECULAR WEIGHT CAPABILITY AND ULTRA-LOW COMONOMER INCORPORATION DOW GLOBAL TECHNOLOGIES LLC (US) 2022-05-26 — — US disclosed
EP-3947481-A1 MONOBIDENTATE AMINOPYRIDINE GROUP IV TRANSITION METAL OLEFIN COPOLYMERIZATION CATALYSTS WITH ULTRA-HIGH MOLECULAR WEIGHT CAPABILITY AND ULTRA-LOW COMONOMER INCORPORATION Dow Global Technologies LLC (US) 2022-02-09 — — EP disclosed
US-20220025085-A1 BIARYL HYDROXYTHIOPHENE GROUP IV TRANSITION METAL POLYMERIZATION CATALYSTS WITH CHAIN TRANSFER CAPABILITY DOW GLOBAL TECHNOLOGIES LLC (US) 2022-01-27 — — US disclosed
EP-3935091-A1 BIARYL HYDROXYTHIOPHENE GROUP IV TRANSITION METAL POLYMERIZATION WITH CHAIN TRANSFER CAPABILITY Dow Global Technologies LLC (US) 2022-01-12 — — EP disclosed
CN-113748138-A Biaryl hydroxythiophene group IV transition metal polymerization with chain transfer capability 陶氏环球技术有限责任公司 2021-12-03 — — CN disclosed
CN-113597438-A Mono-tooth aminopyridine group IV transition metal olefin copolymerization catalyst with ultra-high molecular weight capability and ultra-low comonomer combination 陶氏环球技术有限责任公司 2021-11-02 — — CN disclosed
CN-113348186-A Biaryl hydroxy thiophene IV group transition metal polymerization catalyst with chain transfer capability 陶氏环球技术有限责任公司 2021-09-03 — — CN disclosed
WO-2020197907-A1 MONOBIDENTATE AMINOPYRIDINE GROUP IV TRANSITION METAL OLEFIN COPOLYMERIZATION CATALYSTS WITH ULTRA-HIGH MOLECULAR WEIGHT CAPABILITY AND ULTRA-LOW COMONOMER INCORPORATION DOW GLOBAL TECHNOLOGIES LLC (US) 2020-10-01 — — WO disclosed
WO-2020185494-A1 BIARYL HYDROXYTHIOPHENE GROUP IV TRANSITION METAL POLYMERIZATION WITH CHAIN TRANSFER CAPABILITY DOW GLOBAL TECHNOLOGIES LLC (US) 2020-09-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220025085-A1 BIARYL HYDROXYTHIOPHENE GROUP IV TRANSITION METAL POLYMERIZATION CATALYSTS WITH CHAIN TRANSFER CAPABILITY TRMT1, GFPT1, BCAT1 NQO1 299/4885CYP2A6 749/4885HDAC1 2568/4885
US-12122862-B2 Biaryl hydroxythiophene group IV transition metal polymerization catalysts with chain transfer capability TRMT1, GFPT1, BCAT1 NQO1 299/4885CYP2A6 749/4885HDAC1 2568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback