Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.50 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2587522 | 0.84 | THRB (0.64) | THRBPDE6DTHRAALDH1A1TP53 | |
| Water SCHEMBL27707576 | 0.80 | THRB (0.56) | THRBPDE6DTHRAALDH1A1TP53 | |
| SCHEMBL23466928 | 0.77 | THRB (0.50) | THRBALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL2583822 | 0.77 | THRB (0.58) | THRBPDE6DALDH1A1TP53HSD17B10 | |
| SCHEMBL28916 | 0.77 | THRB (0.58) | THRBPDE6DTHRAALDH1A1TP53 | |
| SCHEMBL14173219 | 0.77 | THRB (0.58) | THRBPDE6DALDH1A1TP53HSD17B10 | |
| SCHEMBL802752 | 0.77 | THRB (0.58) | THRBPDE6DTHRAALDH1A1TP53 | |
| SCHEMBL31379798 | 0.77 | THRB (0.58) | THRBPDE6DTHRAALDH1A1TP53 | |
| Hydrogen Peroxide SCHEMBL28479331 | 0.77 | THRB (0.58) | THRBPDE6DTHRAALDH1A1TP53 | |
| SCHEMBL15695636 | 0.77 | THRB (0.58) | THRBPDE6DTHRAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 447 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268375-B1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2022-06-15 | — | — | EP | claimed |
| EP-3071576-B9 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-12-22 | — | — | EP | claimed |
| EP-3645540-B1 | SILOLE AND GERMOLE FUSED RING PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2021-11-03 | — | — | EP | claimed |
| EP-3071576-B1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-08-18 | — | — | EP | claimed |
| CN-105199708-B | Photochromic compounds | 光学转变公司 | 2020-10-27 | — | — | CN | claimed |
| US-20200172798-A1 | Silole and Germole Fused Ring Photochromic Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-04 | — | — | US | claimed |
| EP-3645540-A1 | SILOLE AND GERMOLE FUSED RING PHOTOCHROMIC COMPOUNDS | Transitions Optical, Ltd. (IE) | 2020-05-06 | — | — | EP | claimed |
| EP-3621958-A1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | Transitions Optical, Ltd. (IE) | 2020-03-18 | — | — | EP | claimed |
| CN-110799514-A | Silole and germacyclopentadiene fused ring photochromic compounds | 光学转变有限公司 | 2020-02-14 | — | — | CN | claimed |
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-02-13 | — | — | US | claimed |
| EP-2359169-A1 | CLEAR TO CIRCULAR POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2011-08-24 | — | — | EP | claimed |
| US-20110140056-A1 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | claimed |
| US-20110143141-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | claimed |
| WO-2011071794-A1 | PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | WO | claimed |
| US-20110135850-A1 | PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION | TRANSITIONS OPTICAL, INC. (US) | 2011-06-09 | — | — | US | claimed |
| US-20110129678-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | claimed |
| WO-2010080311-A1 | CLEAR TO CIRCULAR POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2010-07-15 | — | — | WO | claimed |
| WO-2010065393-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2010-06-10 | — | — | WO | claimed |
| US-20090309076-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2009-12-17 | — | — | US | claimed |
| US-20090135462-A1 | CLEAR TO CIRCULAR POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2009-05-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | ALDH1A2, RB1, INCENP | THRB 4353/4885PDE6D 27/4885THRA 4482/4885 |
| US-20110143141-A1 | Photochromic compounds and compositions | CCNA1, CRY1, CCNT1 | THRB 4544/4885PDE6D 407/4885THRA 3898/4885 |
| US-20200172798-A1 | Silole and Germole Fused Ring Photochromic Compounds | CCNB2, SKP2, CCNB1 | THRB 4196/4885PDE6D 402/4885THRA 4237/4885 |
| US-20110140056-A1 | Indeno-fused ring compounds | CRY2, SQOR, INTS6 | THRB 4093/4885PDE6D 76/4885THRA 3761/4885 |
| US-20110129678-A1 | Photochromic compounds and compositions | CRY2, CRY1, PPOX | THRB 4801/4885PDE6D 82/4885THRA 4829/4885 |
| US-20090309076-A1 | PHOTOCHROMIC COMPOUNDS | CCR4, CCR8, CBR3 | THRB 1098/4885PDE6D 1181/4885THRA 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.