Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PNLIP | P16233 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453332 | 0.93 | LMNA (0.41) | TOP1LMNAKDM4EP2RX7EPHX2 | |
| SCHEMBL22453440 | 0.92 | TOP1 (0.39) | TDP1TOP1LMNAGAAKDM4E | |
| SCHEMBL22453398 | 0.91 | KMT2A (0.37) | TDP1TOP1LMNAGAAKDM4E | |
| SCHEMBL22452986 | 0.86 | AKR1C3 (0.40) | TDP1TOP1LMNAKDM4EFABP3 | |
| SCHEMBL22452447 | 0.85 | KMT2A (0.41) | TOP1LMNAKDM4EP2RX7SMN1; SMN2 | |
| SCHEMBL22453654 | 0.81 | AKR1C3 (0.35) | TDP1MEN1KMT2A | |
| SCHEMBL22452454 | 0.81 | LMNA (0.40) | TOP1LMNAP2RX7SMN1; SMN2FABP3 | |
| SCHEMBL22453356 | 0.77 | HTR2C (0.32) | EPHX2MEN1KMT2A | |
| SCHEMBL22453760 | 0.76 | RAB9A (0.40) | TOP1GAASMN1; SMN2MAPTMEN1 | |
| SCHEMBL22453159 | 0.72 | PDE7A (0.43) | LMNAKDM4EEPHX2SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |