Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453440 | 0.93 | TOP1 (0.39) | MEN1KMT2AHIF1APTGS2LMNA | |
| SCHEMBL22453332 | 0.91 | LMNA (0.41) | AKR1C3MEN1KMT2ALMNAMAPT | |
| SCHEMBL22453074 | 0.89 | PARP1 (0.41) | AKR1C3MEN1KMT2AHIF1APTGS2 | |
| SCHEMBL22453441 | 0.86 | TDP1 (0.37) | MEN1KMT2ALMNACYP3A4MAPT | |
| SCHEMBL22452447 | 0.82 | KMT2A (0.41) | AKR1C3MEN1KMT2ALMNAMAPT | |
| SCHEMBL22453069 | 0.79 | RAB9A (0.47) | MEN1KMT2ALMNAMAPTPARP1 | |
| SCHEMBL22452454 | 0.78 | LMNA (0.40) | AKR1C3MEN1KMT2ALMNAMAPT | |
| SCHEMBL22453356 | 0.78 | HTR2C (0.32) | MEN1KMT2AHTR2ANPC1KCNH2 | |
| SCHEMBL22452811 | 0.76 | HIF1A (0.52) | AKR1C3MEN1KMT2AHIF1ATTR | |
| SCHEMBL22452805 | 0.74 | FABP4 (0.47) | AKR1C3MEN1KMT2AHIF1APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |