Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 5/20 | 0.73 |
| ▸ | MAOB | P27338 | 6/20 | 0.63 |
| ▸ | MAOA | P21397 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | CES1 | P23141 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377143 | 0.86 | TGM2 (0.69) | TGM2MAOBMAOASMN1; SMN2CES1 | |
| SCHEMBL5327486 | 0.85 | MAOA (0.63) | TGM2MAOBMAOASMN1; SMN2CES1 | |
| SCHEMBL4138108 | 0.85 | TGM2 (1.00) | TGM2MAOBMAOACES1ALDH1A1 | |
| SCHEMBL8671077 | 0.85 | MAOB (0.83) | TGM2MAOBMAOACES1ALDH1A1 | |
| SCHEMBL3742475 | 0.83 | MAOB (0.70) | TGM2MAOBMAOASMN1; SMN2CES1 | |
| SCHEMBL5133044 | 0.82 | MAOB (0.73) | TGM2MAOBMAOASMN1; SMN2CES1 | |
| SCHEMBL16237977 | 0.81 | TGM2 (0.73) | TGM2MAOBMAOACES1ALDH1A1 | |
| SCHEMBL16237905 | 0.81 | TGM2 (0.73) | TGM2MAOBMAOACES1ALDH1A1 | |
| SCHEMBL9885995 | 0.81 | TGM2 (0.73) | TGM2MAOBMAOACES1ALDH1A1 | |
| SCHEMBL16237989 | 0.81 | TGM2 (0.73) | TGM2MAOBMAOACES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384769-B | Synthetic method of R-configuration 3-substituted-3-hydroxy oxindole compound | 陕西师范大学 | 2020-12-22 | — | — | CN | claimed |
| CN-105732460-A | Method for synthesizing indole compound | 常州工程职业技术学院 | 2016-07-06 | — | — | CN | claimed |
| CN-102690226-A | Multi-nitrogen substituted isatin derivative and synthetic method of multi-nitrogen substituted isatin derivative | UNIV GUANGDONG TECHNOLOGY | 2012-09-26 | — | — | CN | claimed |
| US-20250099438-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS FOR TREATING CANCER, GLIOBLASTOMA, AND OTHER INDICATIONS | UNIVERSITY OF MARYLAND, BALTIMORE | 2025-03-27 | — | — | US | disclosed |
| US-12194027-B2 | Small molecule inhibitors of GPCR GPR68 and related receptors for treating cancer, glioblastoma, and other indications | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2025-01-14 | — | — | US | disclosed |
| US-20240327364-A1 | THERAPEUTIC TARGETING OF GPR68 TO INDUCE FERROPTOSIS | UNIVERSITY OF MARYLAND, BALTIMORE | 2024-10-03 | — | — | US | disclosed |
| US-20220202785-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS FOR TREATING CANCER, GLIOBLASTOMA, AND OTHER INDICATIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-06-30 | — | — | US | disclosed |
| EP-3955922-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS | University of Maryland, Baltimore (US) | 2022-02-23 | — | — | EP | disclosed |
| CN-109384769-B | Synthetic method of R-configuration 3-substituted-3-hydroxy oxindole compound | 陕西师范大学 | 2020-12-22 | — | — | CN | disclosed |
| WO-2020214896-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2020-10-22 | — | — | WO | disclosed |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. | 2020-02-13 | — | — | US | disclosed |
| US-5773613-A | HEAT AND WEAR RESISTANT; DURABILITY | MITA INDUSTRIAL CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| EP-0379145-B1 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID CO (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5585378-A | Composition containing an oxoindole compound | AKTIEBOLAGET ASTRA (SE) | 1996-12-17 | — | — | US | disclosed |
| EP-0718298-A1 | Electron transporting tryptoanthrinime derivatives | MITA INDUSTRIAL CO. LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |
| EP-0624156-A1 | ISATIN DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Astra Aktiebolag (SE) | 1994-11-17 | — | — | EP | disclosed |
| CN-1079464-A | Treatment comprises the preparation method of the valuable indolone of illness of cholinergic function reduction and the derivative of indole dione | ASTRA AB (SE) | 1993-12-15 | — | — | CN | disclosed |
| WO-1993012085-A1 | ISATIN DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | AKTIEBOLAGET ASTRA (SE) | 1993-06-24 | — | — | WO | disclosed |
| US-4968702-A | ANTIARTHRITIC, INHIBITORS OF PROGRESSIVE JOINT DETERIORATION, IMMUNOSUPPRESSANT | AMERICAN CYANAMID COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0379145-A2 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240327364-A1 | THERAPEUTIC TARGETING OF GPR68 TO INDUCE FERROPTOSIS | GPR68, GPR65, GPR84 | TGM2 384/4885MAOB 4741/4885MAOA 4727/4885 |
| US-20250099438-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS FOR TREATING CANCER, GLIOBLASTOMA, AND OTHER INDICATIONS | GPR68, GPR65, GPR4 | TGM2 773/4885MAOB 4294/4885MAOA 4158/4885 |
| US-12194027-B2 | Small molecule inhibitors of GPCR GPR68 and related receptors for treating cancer, glioblastoma, and other indications | GPR68, GPR65, GPR4 | TGM2 773/4885MAOB 4294/4885MAOA 4158/4885 |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | SMYD3, SMYD2, SMURF2 | TGM2 2061/4885MAOB 2201/4885MAOA 3442/4885 |
| US-20220202785-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS FOR TREATING CANCER, GLIOBLASTOMA, AND OTHER INDICATIONS | GPR68, GPR65, GPR4 | TGM2 773/4885MAOB 4294/4885MAOA 4158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.