Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9632175 | 0.86 | TET2 (0.58) | TET2RECQLTSHRHSD17B10ALDH1A1 | |
| SCHEMBL11184401 | 0.78 | ALDH1A1 (0.56) | TET2RECQLTSHRHSD17B10ALDH1A1 | |
| SCHEMBL523837 | 0.78 | CA2 (0.59) | TET2RECQLTSHRHSD17B10ALDH1A1 | |
| SCHEMBL9853078 | 0.77 | RECQL (0.64) | TET2RECQLTSHRHSD17B10GAA | |
| SCHEMBL18183362 | 0.77 | TET2 (0.54) | TET2RECQLTSHRHSD17B10ALDH1A1 | |
| SCHEMBL468803 | 0.76 | — | — | |
| SCHEMBL10555722 | 0.76 | — | — | |
| SCHEMBL14440166 | 0.75 | TET2 (0.47) | TET2RECQLTSHRHSD17B10ALDH1A1 | |
| SCHEMBL24376281 | 0.74 | — | — | |
| SCHEMBL7826416 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170897-B1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | UNIV BROCK (CA) | 2013-08-21 | — | — | EP | claimed |
| US-7999104-B2 | Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids | BROCK UNIVERSITY (CA) | 2011-08-16 | — | — | US | claimed |
| EP-2170897-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | Brock University (CA) | 2010-04-07 | — | — | EP | claimed |
| WO-2009003270-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY (CA) | 2009-01-08 | — | — | WO | claimed |
| US-20090005565-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY | 2009-01-01 | — | — | US | claimed |
| US-9340550-B2 | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids | BROCK UNIVERSITY (CA) | 2016-05-17 | — | — | US | disclosed |
| US-20150152120-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-FUNCTIONALIZATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY (CA) | 2015-06-04 | — | — | US | disclosed |
| US-8962841-B2 | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids | BROCK UNIVERSITY (CA) | 2015-02-24 | — | — | US | disclosed |
| EP-2170897-B1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | UNIV BROCK (CA) | 2013-08-21 | — | — | EP | disclosed |
| US-20110313163-A1 | Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids | BROCK UNIVERSITY (CA) | 2011-12-22 | — | — | US | disclosed |
| US-7999104-B2 | Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids | BROCK UNIVERSITY (CA) | 2011-08-16 | — | — | US | disclosed |
| EP-2170897-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | Brock University (CA) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009003270-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY (CA) | 2009-01-08 | — | — | WO | disclosed |
| US-20090005565-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | BROCK UNIVERSITY | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152120-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-FUNCTIONALIZATION OF MORPHINE AND TROPANE ALKALOIDS | PNMT, HNMT, OPRM1 | TET2 18/4885RECQL 4510/4885TSHR 1845/4885 |
| US-20110313163-A1 | Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids | PNMT, HNMT, OPRM1 | TET2 18/4885RECQL 4510/4885TSHR 1845/4885 |
| US-20090005565-A1 | METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS | HNMT, PNMT, NNMT | TET2 26/4885RECQL 4706/4885TSHR 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.