Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.50 |
| ▸ | CTSL | P07711 | 5/20 | 0.50 |
| ▸ | CTSS | P25774 | 6/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22494016 | 1.00 | CTSK (0.50) | CTSKCTSLCTSSCTSBBCHE | |
| SCHEMBL29360411 | 0.92 | CTSS (0.54) | CTSKCTSLCTSSCTSBBCHE | |
| SCHEMBL29362656 | 0.88 | SIRT2 (0.50) | CTSKCTSL | |
| SCHEMBL29360762 | 0.87 | PSMB8 (0.50) | CTSKCTSLCTSSCTSBBCHE | |
| SCHEMBL22534071 | 0.86 | CTSL (0.54) | CTSKCTSLCTSSBCHEACHE | |
| SCHEMBL29361478 | 0.84 | CTSS (0.57) | CTSKCTSLCTSSCTSBBCHE | |
| SCHEMBL992795 | 0.83 | CA12 (0.59) | CTSKCTSLCTSSCTSBCACNA1C | |
| SCHEMBL29362776 | 0.83 | SIRT5 (0.48) | CTSKCTSL | |
| SCHEMBL29362605 | 0.82 | SMN1; SMN2 (0.58) | CTSKCTSLCTSSCTSBBCHE | |
| Trifluoroacetic Acid SCHEMBL21571447 | 0.82 | SIRT2 (0.51) | CTSKCTSLCTSSCTSBBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | Venenum Biodesign, LLC (US) | 2023-02-21 | — | — | US | disclosed |
| US-20220213111-A1 | SUBSTITUTED HETEROCYCLES AS CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2022-07-07 | — | — | US | disclosed |
| US-11306098-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | Venenum Biodesign, LLC (US) | 2022-04-19 | — | — | US | disclosed |
| EP-3953333-A1 | NOVEL CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2022-02-16 | — | — | EP | disclosed |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2021-01-21 | — | — | US | disclosed |
| US-20200317677-A1 | NOVEL CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317677-A1 | NOVEL CYCLIC TREX1 INHIBITORS | TMX1, TCOF1, TREH | CTSK 3817/4885CTSL 3165/4885CTSS 3067/4885 |
| US-20220213111-A1 | SUBSTITUTED HETEROCYCLES AS CYCLIC TREX1 INHIBITORS | TMX1, TREH, TSNAX | CTSK 3200/4885CTSL 3028/4885CTSS 2838/4885 |
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | TMX1, P2RX1, TCOF1 | CTSK 4170/4885CTSL 3478/4885CTSS 3702/4885 |
| US-11306098-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | TMX1, P2RX1, TCOF1 | CTSK 4194/4885CTSL 3416/4885CTSS 3672/4885 |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | TMX1, TSNAX, TPX2 | CTSK 3827/4885CTSL 3372/4885CTSS 3274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.