Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.53 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.51 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407613 | 0.90 | PIN1 (0.64) | CA2CA1PIN1PTPN1 | |
| SCHEMBL2245325 | 0.90 | CA2 (0.69) | CA2CA1C3AR1MMP2MMP9 | |
| SCHEMBL2246061 | 0.90 | CA2 (0.69) | CA2CA1C3AR1MMP2MMP9 | |
| SCHEMBL2248592 | 0.86 | DHFR (0.54) | CA2CA1PIN1CTSLCTSB | |
| SCHEMBL2249553 | 0.86 | MMP12 (0.67) | CA1UTS2RMMP12CTSLCTSB | |
| SCHEMBL2248738 | 0.84 | HPGDS (0.60) | CA2CA1C3AR1MMP2MMP9 | |
| SCHEMBL5260684 | 0.83 | CA2 (0.70) | CA2CA1C3AR1MMP2MMP9 | |
| SCHEMBL5260686 | 0.83 | CA2 (0.70) | CA2CA1C3AR1MMP2MMP9 | |
| SCHEMBL2252396 | 0.82 | CA2 (0.57) | CA2CA1C3AR1MMP2MMP9 | |
| SCHEMBL2245609 | 0.82 | CA2 (0.66) | CA2CA1C3AR1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |