Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22562067 | 0.78 | CYP2D6 (0.40) | — | |
| SCHEMBL22561935 | 0.70 | — | — | |
| SCHEMBL22561885 | 0.65 | GABRA1 (0.38) | — | |
| SCHEMBL20008807 | 0.59 | LDLR (0.31) | LDLRNPC1RAB9A | |
| SCHEMBL22561897 | 0.56 | — | — | |
| SCHEMBL24060059 | 0.55 | RAB9A (0.72) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL14435612 | 0.53 | MGLL (0.37) | LDLRNPC1RAB9AALDH1A1 | |
| SCHEMBL24746313 | 0.53 | NPC1 (0.62) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL26145831 | 0.53 | HPGD (0.51) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL18664789 | 0.52 | ALDH1A1 (0.60) | NPC1RAB9AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191467-B1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2020-10-21 | — | — | EP | disclosed |