SCHEMBL2268189

SCHEMBL2268189

Cc1ccccc1C(=O)Nc1cc(-c2ccccc2)ccc1C(=O)O

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ACLY P53396 8/20 0.61
DHODH Q02127 1/20 0.56
HPGD P15428 1/20 0.54
KDM4E B2RXH2 1/20 0.53
ALDH1A1 P00352 1/20 0.53
POLB P06746 1/20 0.53
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
HDAC1 Q13547 1/20 0.52
SUCNR1 Q9BXA5 1/20 0.52
SLC16A3 O15427 1/20 0.52
MAPT P10636 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.50
MCL1 Q07820 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275722 0.91 ACLY (0.57) ACLYDHODHKDM4EPOLBNPC1
SCHEMBL1317226 0.89 ACLY (0.56) ACLYDHODHHPGDKDM4EALDH1A1
SCHEMBL27970823 0.85 HPGD (0.64) DHODHHPGDKDM4EALDH1A1POLB
SCHEMBL2272508 0.84 ACLY (0.63) ACLYDHODHALDH1A1HDAC1SUCNR1
SCHEMBL27743215 0.84 SLC16A3 (0.56) HPGDKDM4EALDH1A1POLBRAB9A
SCHEMBL2272453 0.84 ACLY (0.63) ACLYDHODHHPGDKDM4EALDH1A1
SCHEMBL8252530 0.83 ALDH1A1 (0.72) DHODHHPGDKDM4EALDH1A1POLB
SCHEMBL2269604 0.83 ACLY (0.69) ACLYDHODHHPGDSUCNR1
SCHEMBL5145099 0.83 ACLY (0.61) ACLYDHODHNPC1RAB9AHDAC1
SCHEMBL2278464 0.83 ACLY (0.49) ACLYDHODHKDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ACLY 653/4885DHODH 1469/4885HPGD 274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.