SCHEMBL2278464

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2275722	0.92	ACLY (0.57)	ACLYNPC1RAB9ALMNAHSD17B10
	SCHEMBL2276321	0.85	ACLY (0.56)	ACLYNPC1RAB9ASUCNR1HCAR2
	SCHEMBL1317226	0.84	ACLY (0.56)	ACLYNPC1RAB9AHSD17B10SUCNR1
	SCHEMBL2268189	0.83	ACLY (0.61)	ACLYNPC1RAB9ASUCNR1DHODH
	SCHEMBL2274223	0.82	ALDH1A1 (0.53)	NPC1RAB9AHSD17B10TP53TSHR
	SCHEMBL12117713	0.81	ALDH1A1 (0.50)	ACLYNPC1RAB9ALMNAHSD17B10
	SCHEMBL12395483	0.81	ACLY (0.42)	ACLYNPC1RAB9ALMNAHSD17B10
	SCHEMBL2278485	0.79	LMNA (0.48)	ACLYNPC1RAB9ALMNAHSD17B10
	SCHEMBL2274974	0.79	ACLY (0.67)	ACLYSUCNR1MEN1KMT2ATDP1
	SCHEMBL2275333	0.78	MAOB (0.54)	NPC1RAB9ALMNAHSD17B10TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.