Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22438582 | 0.72 | CXCR3 (0.43) | PDE2AHDAC6MCHR1P2RX7HDAC4 | |
| SCHEMBL22686819 | 0.67 | TP53 (0.46) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685163 | 0.67 | PDE2A (0.44) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685252 | 0.67 | PDE2A (0.32) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685086 | 0.67 | WDR91 (0.43) | PDE2AMCHR1PDE10AKCNH2 | |
| SCHEMBL22685253 | 0.66 | PDE2A (0.42) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL23499863 | 0.65 | KIF11 (0.50) | MCHR1PDE10AKCNH2MAP4K4PIK3CA | |
| SCHEMBL2340659 | 0.65 | CA12 (0.53) | MCHR1KCNH2MAP4K4PIK3CAMINK1 | |
| SCHEMBL21123638 | 0.64 | TRPV4 (0.42) | PDE2APDE10AP2RX7 | |
| SCHEMBL2340910 | 0.64 | RXRA (0.53) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |