Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | MST1R | Q04912 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22685179 | 0.76 | IDO1 (0.37) | PDE2APTGER4PTGDRCYP2C9IDO1 | |
| SCHEMBL22685247 | 0.75 | ROCK2 (0.41) | MAP4K4ROCK1PDE2AHDAC3HDAC1 | |
| SCHEMBL22685245 | 0.75 | MAP4K4 (0.41) | MAP4K4PDE2ACYP2C9IDO1 | |
| SCHEMBL22685250 | 0.75 | PTPN1 (0.40) | RETROCK1PDE2AHDAC3HDAC1 | |
| SCHEMBL22685175 | 0.75 | IDO1 (0.37) | PDE2AHDAC3HDAC1PTGER4PTGDR | |
| SCHEMBL22685074 | 0.70 | IDO1 (0.51) | MAP4K4PDE2AHDAC3HDAC1CYP2C9 | |
| SCHEMBL22685078 | 0.70 | WDR91 (0.53) | MAP4K4PDE2ACYP2C9IDO1 | |
| SCHEMBL22685072 | 0.70 | IDO1 (0.43) | PDE2AHDAC3HDAC1CYP2C9IDO1 | |
| SCHEMBL22685073 | 0.68 | IDO1 (0.41) | MAP4K4PDE2ACYP2C9IDO1 | |
| SCHEMBL22685177 | 0.67 | IDO1 (0.42) | MAP4K4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |