Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FURIN | P09958 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.33 |
| ▸ | MMP3 | P08254 | 4/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21152822 | 0.85 | SIRT6 (0.44) | SIRT6SIRT1SMN1; SMN2FURINBIRC2 | |
| SCHEMBL21914973 | 0.83 | SMN1; SMN2 (0.33) | SIRT6SIRT1SMN1; SMN2FURINNOD1 | |
| SCHEMBL23106115 | 0.82 | SMN1; SMN2 (0.33) | SIRT6SIRT1SMN1; SMN2FURIN | |
| SCHEMBL20385879 | 0.80 | SMN1; SMN2 (0.39) | SIRT6SIRT1SMN1; SMN2FURINBIRC2 | |
| SCHEMBL21915906 | 0.77 | SIRT6 (0.36) | SIRT6SIRT1SMN1; SMN2FURINBIRC2 | |
| SCHEMBL24703694 | 0.77 | SMN1; SMN2 (0.32) | SIRT6SIRT1SMN1; SMN2FURIN | |
| SCHEMBL25070732 | 0.76 | SIRT6 (0.41) | SIRT6SIRT1SMN1; SMN2FURINNOD1 | |
| SCHEMBL21915070 | 0.76 | SIRT6 (0.41) | SIRT6SIRT1SMN1; SMN2FURINNOD1 | |
| SCHEMBL22702596 | 0.76 | CTSL (0.47) | SIRT6SIRT1FURINNOD1TLR2 | |
| SCHEMBL24173258 | 0.76 | C3AR1 (0.34) | SIRT6SIRT1SMN1; SMN2FURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844090-B2 | Hemiasterlin derivatives for conjugation and therapy | SUTRO BIOPHARMA, INC. (US) | 2020-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844090-B2 | Hemiasterlin derivatives for conjugation and therapy | CYP17A1, HSD17B7, SHBG | SIRT6 2884/4885SIRT1 2724/4885SMN1; SMN2 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.