SCHEMBL2270432

SCHEMBL2270432

CC(C)(C)OC(=O)c1ccc(-c2ccc3c(c2)OCO3)cc1N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 3/20 0.46
PRKCI P41743 1/20 0.46
SCD5 Q86SK9 1/20 0.45
RIPK2 O43353 1/20 0.44
CA12 O43570 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
ALDH1A1 P00352 3/20 0.41
HPGD P15428 3/20 0.41
KDM4E B2RXH2 2/20 0.41
GABRA1 P14867 2/20 0.41
GABRB2 P47870 2/20 0.41
MAPK1 P28482 2/20 0.41
KMT2A Q03164 2/20 0.41
RAB9A P51151 2/20 0.41
MEN1 O00255 1/20 0.41
TP53 P04637 1/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27696805 0.88 RIPK2 (0.42) PRKCZPRKCISCD5RIPK2CA12
SCHEMBL2270196 0.81 ABCB1 (0.49) SCD5RIPK2CA12CA2CA9
SCHEMBL12394331 0.79 PPM1B (0.54) CA12CA2CA9ALDH1A1HPGD
SCHEMBL1315998 0.78 IKBKB (0.47) CA12CA2CA9ALDH1A1HPGD
SCHEMBL4223709 0.77 ALDH1A1 (0.45) ALDH1A1HPGDKDM4EKMT2ARAB9A
SCHEMBL2262407 0.76 GABRA1 (0.44) PRKCZPRKCISCD5ALDH1A1HPGD
SCHEMBL2501789 0.75 CTSA (0.48) SCD5ALDH1A1HPGDKDM4EGABRA1
SCHEMBL2276199 0.75 ALDH1A1 (0.51) ALDH1A1HPGDKDM4EKMT2ARAB9A
SCHEMBL2275420 0.74 ELANE (0.50) CA12CA2CA9ALDH1A1HPGD
SCHEMBL2272793 0.74 PGR (0.51) ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PRKCZ 4005/4885PRKCI 4020/4885SCD5 3645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.