SCHEMBL2270545

SCHEMBL2270545

CC(C)(C)OC(=O)c1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1NC(=O)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.56
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
PYGL P06737 8/20 0.49
PYGM P11217 2/20 0.49
CRHBP P24387 1/20 0.49
CRHR2 Q13324 1/20 0.49
KDM4E B2RXH2 1/20 0.49
MAPT P10636 3/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
MAPK1 P28482 1/20 0.47
MITF O75030 1/20 0.47
POLB P06746 1/20 0.47
HTT P42858 1/20 0.47
ERO1A Q96HE7 1/20 0.47
SNCA P37840 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274803 0.92 PYGL (0.55) FFAR1MEN1KMT2APYGLPYGM
SCHEMBL27716645 0.91 FFAR1 (0.55) FFAR1MEN1KMT2APYGLPYGM
SCHEMBL2271414 0.88 KMT2A (0.54) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL2269139 0.86 CYP2C9 (0.47) MEN1KMT2APYGLPYGMKDM4E
SCHEMBL2273149 0.86 MEN1 (0.66) FFAR1MEN1KMT2APYGLPYGM
SCHEMBL2276677 0.85 SNCA (0.59) MEN1KMT2AKDM4EMAPTNPC1
SCHEMBL2276669 0.85 SNCA (0.59) MEN1KMT2AKDM4EMAPTNPC1
SCHEMBL27696971 0.84 PYGL (0.53) FFAR1MEN1KMT2APYGLPYGM
SCHEMBL2269667 0.83 F10 (0.53) MEN1KMT2APYGMKDM4EMAPT
SCHEMBL2274133 0.83 MEN1 (0.64) FFAR1MEN1KMT2APYGLPYGM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 FFAR1 1952/4885MEN1 3105/4885KMT2A 1669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.