SCHEMBL2273149

SCHEMBL2273149

O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.66
KMT2A Q03164 3/20 0.66
FFAR1 O14842 1/20 0.64
PYGL P06737 10/20 0.61
PYGM P11217 2/20 0.61
KDM4E B2RXH2 1/20 0.60
ERO1A Q96HE7 1/20 0.58
CRHBP P24387 1/20 0.56
CRHR2 Q13324 1/20 0.56
NPC1 O15118 1/20 0.54
MITF O75030 1/20 0.54
POLB P06746 1/20 0.54
RAB9A P51151 1/20 0.54
MAPT P10636 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274133 0.96 MEN1 (0.64) MEN1KMT2AFFAR1PYGLPYGM
SCHEMBL2271374 0.91 PYGL (0.67) MEN1KMT2AFFAR1PYGLPYGM
SCHEMBL2272594 0.90 PYGL (0.72) MEN1KMT2AFFAR1PYGLPYGM
SCHEMBL2271588 0.87 SERPINE1 (0.64) MEN1KMT2APYGLPYGMNPC1
SCHEMBL2270545 0.86 FFAR1 (0.56) MEN1KMT2AFFAR1PYGLPYGM
SCHEMBL27716645 0.85 FFAR1 (0.55) MEN1KMT2AFFAR1PYGLPYGM
SCHEMBL2276538 0.84 CD40 (0.65) MEN1KMT2AERO1ANPC1MITF
SCHEMBL2274898 0.84 SERPINE1 (0.60) MEN1KMT2APYGLPYGMNPC1
SCHEMBL2274811 0.83 PYGM (0.57) MEN1KMT2APYGLPYGMPOLB
SCHEMBL2273044 0.83 CYP2C9 (0.61) MEN1KMT2APYGLPYGMMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885FFAR1 1952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.