Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 9/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | SMPD2 | O60906 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752950 | 0.82 | TXNRD1 (0.48) | SMPD3AKT1CNR2OPRM1OPRD1 | |
| SCHEMBL2412747 | 0.80 | AKT1 (0.46) | SMPD3AKT1CNR2MTNR1AMTNR1B | |
| SCHEMBL2413631 | 0.79 | AKT1 (0.45) | SMPD3AKT1MTNR1AMTNR1BOPRM1 | |
| SCHEMBL2412636 | 0.79 | SUV39H2 (0.49) | SMPD3AKT1SUV39H2 | |
| SCHEMBL3645853 | 0.77 | AKT1 (0.53) | SMPD3AKT1CNR2MTNR1AMTNR1B | |
| SCHEMBL3946323 | 0.76 | AKT1 (0.49) | SMPD3AKT1SUV39H2CACNA2D1SMPD2 | |
| SCHEMBL2415078 | 0.76 | SMPD3 (0.46) | SMPD3AKT1MTNR1AMTNR1BOPRM1 | |
| SCHEMBL11144665 | 0.73 | HRH3 (0.54) | SMPD3SUV39H2 | |
| SCHEMBL2416387 | 0.73 | MTNR1A (0.44) | SMPD3AKT1MTNR1AMTNR1BSUV39H2 | |
| SCHEMBL5755839 | 0.73 | ADORA2A (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1413286-B1 | Dyeing composition comprising at least one heterocyclic oxidation base and at least one substituted 2,3-diaminopyridine as a coupling agent | OREAL (FR) | 2009-04-22 | — | — | EP | claimed |
| EP-1336606-B1 | 6-Alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibers | OREAL (FR) | 2006-12-27 | — | — | EP | claimed |
| EP-1586303-A1 | Dye composition comprising at least one diaminopyrazole as oxidation base and at least one 6-alkoxy-2,3-diaminopyridine as coupler | L'OREAL (FR) | 2005-10-19 | — | — | EP | claimed |
| EP-1586302-A1 | Dye composition comprising at least one pyrazolopyrimidine as oxidation base and at least one 6-alkoxy-2,3-diaminopyridine as coupler | L'OREAL (FR) | 2005-10-19 | — | — | EP | claimed |
| US-6916345-B2 | 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-07-12 | — | — | US | claimed |
| US-20040231067-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses | L'OREAL (FR) | 2004-11-25 | — | — | US | claimed |
| EP-1457198-A1 | Dyeing composition comprising at least one diaminopyrazole precursor and at least one 6-alcoxy 2,3-diaminopyridine coupler | L'OREAL (FR) | 2004-09-15 | — | — | EP | claimed |
| EP-1428510-A1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a heterocyclic coupler or a hydroxybenzamide ; method and use | L'OREAL (FR) | 2004-06-16 | — | — | EP | claimed |
| EP-1413286-A1 | Dyeing composition comprising at least one heterocyclic oxidation base and at least one substituted 2,3-diaminopyridine as a coupling agent | L'OREAL (FR) | 2004-04-28 | — | — | EP | claimed |
| EP-1405628-A1 | Dyeing composition comprising at least one pyrazolopyrimidine oxidation base and at least one 6-alkoxy-2,3-diaminopyrimidine coupler | L'OREAL (FR) | 2004-04-07 | — | — | EP | claimed |
| US-20030226216-A1 | Novel 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres | L'OREAL S.A. (FR) | 2003-12-11 | — | — | US | claimed |
| EP-1336606-A1 | 6-Alkoxy-2,3-diaminopyridine couplers for dying keratin fibers | L'OREAL (FR) | 2003-08-20 | — | — | EP | claimed |
| EP-2182914-B1 | COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF | L'ORÉAL (FR) | 2017-11-08 | — | — | EP | disclosed |
| EP-2175830-B1 | COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES | ORÉAL L (FR) | 2015-09-30 | — | — | EP | disclosed |
| US-8043385-B2 | Composition oxidation colouring of keratinic fibres, containing a cationic cellulose ether, a metasilicate and oxidation dyes, method for oxidation colouring and uses thereof | L'OREAL S.A. (FR) | 2011-10-25 | — | — | US | disclosed |
| US-8002847-B2 | Composition for oxidation dyeing keratin fibres comprising a cationic cellulose ether, a weakly oxyethylenated sorbitan fatty acid ester and oxidation dyes | L 'OREAL S.A. (FR) | 2011-08-23 | — | — | US | disclosed |
| EP-1413286-A1 | Dyeing composition comprising at least one heterocyclic oxidation base and at least one substituted 2,3-diaminopyridine as a coupling agent | L'OREAL (FR) | 2004-04-28 | — | — | EP | disclosed |
| EP-1405628-A1 | Dyeing composition comprising at least one pyrazolopyrimidine oxidation base and at least one 6-alkoxy-2,3-diaminopyrimidine coupler | L'OREAL (FR) | 2004-04-07 | — | — | EP | disclosed |
| US-20030226216-A1 | Novel 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres | L'OREAL S.A. (FR) | 2003-12-11 | — | — | US | disclosed |
| EP-1336606-A1 | 6-Alkoxy-2,3-diaminopyridine couplers for dying keratin fibers | L'OREAL (FR) | 2003-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030226216-A1 | Novel 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres | KRT18, DSP, DPYD | SMPD3 2822/4885AKT1 4878/4885CNR2 3379/4885 |
| US-20040231067-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses | KRT18, CDC73, PYCR1 | SMPD3 3844/4885AKT1 4459/4885CNR2 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.