Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22738288 | 0.87 | GABRA5 (0.42) | GABRA5EGLN1NPC1RAB9AMAPT | |
| SCHEMBL1503263 | 0.85 | MMP1 (0.44) | EGLN1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL1503217 | 0.84 | ALDH1A1 (0.43) | NPC1RAB9AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL27812971 | 0.81 | NR4A2 (0.46) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL22738236 | 0.77 | EGLN1 (0.39) | EGLN1NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL22719903 | 0.74 | GRIN1 (0.43) | EGLN1MAPTALDH1A1EGLN2GRIN2B | |
| SCHEMBL12516713 | 0.72 | FAAH (0.44) | MAPTALDH1A1KMT2A | |
| SCHEMBL22719957 | 0.72 | SMN1; SMN2 (0.42) | EGLN1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL22719954 | 0.72 | ALDH1A1 (0.38) | EGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL1503276 | 0.72 | AR (0.40) | EGLN1RAB9AL3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |