SCHEMBL2272869

SCHEMBL2272869

O=C(O)c1ccc(-c2cc3ccccc3o2)cc1[N+](=O)[O-]

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.49
MAOA P21397 3/20 0.48
MAOB P27338 3/20 0.47
CA1 P00915 2/20 0.47
CA9 Q16790 2/20 0.47
CA12 O43570 1/20 0.47
CA3 P07451 1/20 0.47
TSHR P16473 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
CA5A P35218 1/20 0.47
CA7 P43166 1/20 0.47
GPR35 Q9HC97 1/20 0.47
CA14 Q9ULX7 1/20 0.47
CA5B Q9Y2D0 1/20 0.47
NPC1 O15118 2/20 0.46
ALDH1A1 P00352 2/20 0.46
RAB9A P51151 2/20 0.46
KMT2A Q03164 2/20 0.46
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272548 0.83 ALDH1A1 (0.43) ALOX5MAOAMAOBCA1CA9
SCHEMBL12394316 0.79 HDAC2 (0.58) ALOX5MAOAMAOBCA1CA9
SCHEMBL14428907 0.78 KDM4E (0.48) ALOX5MAOACA1CA9NPC1
SCHEMBL5193454 0.77 CRHBP (0.59) TSHRALDH1A1KMT2AMEN1MAPT
SCHEMBL2272018 0.77 HDAC2 (0.62) MAOBNPC1RAB9AKMT2AMEN1
SCHEMBL8375405 0.77 TDP1 (0.52) TSHRALDH1A1KMT2AKDM4EMEN1
Formaldehyde SCHEMBL27611540 0.75 CRHBP (0.56) TSHRKMT2AMEN1MAPTMAPK1
SCHEMBL9131248 0.75 TNKS (0.67) ALOX5MAOBCA1CA9NPC1
SCHEMBL17177737 0.74 DTYMK (0.49) TSHRALDH1A1KMT2AKDM4EMEN1
SCHEMBL980203 0.73 TNKS (0.66) ALOX5MAOAMAOBCA1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ALOX5 621/4885MAOA 802/4885MAOB 1486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.