SCHEMBL2272946

SCHEMBL2272946

O=C(Nc1cc(C2=COC(Cc3ccccc3)O2)ccc1C(=O)O)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 4/20 0.48
HDAC2 Q92769 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
KMT2A Q03164 1/20 0.44
PPARG P37231 3/20 0.43
PPARD Q03181 3/20 0.43
PPARA Q07869 3/20 0.43
NR1H4 Q96RI1 3/20 0.43
GPR35 Q9HC97 1/20 0.42
IGF2BP2 Q9Y6M1 1/20 0.42
PLK1 P53350 1/20 0.41
DHODH Q02127 1/20 0.41
MPO P05164 1/20 0.41
PTGS1 P23219 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.39
KCNK2 O95069 2/20 0.39
KCNK10 P57789 2/20 0.39
LTB4R Q15722 1/20 0.39
LTB4R2 Q9NPC1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274797 0.91 MEN1 (0.46) ACLYHDAC2NPC1RAB9AKMT2A
SCHEMBL2272855 0.91 HDAC2 (0.43) ACLYHDAC2NPC1RAB9AKMT2A
SCHEMBL2272547 0.84 ACLY (0.40) ACLYNPC1RAB9ADHODH
SCHEMBL2276203 0.81 CYP1A2 (0.41) HDAC2RAB9AKMT2AIGF2BP2
SCHEMBL2274231 0.80 ACLY (0.39) ACLYNPC1RAB9AKMT2AMPO
SCHEMBL2274014 0.78 HDAC1 (0.50) ACLYNPC1RAB9AKMT2A
SCHEMBL2270861 0.77 TRPM2 (0.48) NPC1RAB9AKMT2AKCNK2LTB4R
SCHEMBL2267918 0.77 ACLY (0.74) ACLYHDAC2NPC1RAB9AKMT2A
SCHEMBL2273187 0.76 ACLY (0.49) ACLYDHODH
SCHEMBL2269100 0.74 PLK1 (0.56) ACLYNPC1RAB9AKMT2APPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed