SCHEMBL2272855

SCHEMBL2272855

O=C(Nc1cc(C2=COC(Cc3ccccc3)O2)ccc1C(=O)O)c1ccc(F)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.43
DHODH Q02127 1/20 0.42
ACLY P53396 2/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
MAPT P10636 1/20 0.39
PKM P14618 1/20 0.39
GRIK1 P39086 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
KDM4E B2RXH2 3/20 0.39
LMNA P02545 1/20 0.39
IGF2BP2 Q9Y6M1 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
ADCY8 P40145 1/20 0.39
ADCY1 Q08828 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274797 0.93 MEN1 (0.46) HDAC2DHODHACLYMEN1KMT2A
SCHEMBL2272946 0.91 ACLY (0.48) HDAC2DHODHACLYKMT2AIGF2BP2
SCHEMBL2276203 0.89 CYP1A2 (0.41) HDAC2MEN1KMT2ACYP1A2CYP2D6
SCHEMBL2272547 0.86 ACLY (0.40) DHODHACLYNPC1RAB9A
SCHEMBL2274231 0.82 ACLY (0.39) ACLYMEN1KMT2ACYP1A2TSHR
SCHEMBL2274014 0.80 HDAC1 (0.50) ACLYMEN1KMT2ATSHRMAPT
SCHEMBL2270861 0.79 TRPM2 (0.48) MEN1KMT2ACYP1A2CYP2C19MAPT
SCHEMBL2276665 0.79 TTR (0.41) ACLYMEN1KMT2AMAPTKDM4E
SCHEMBL2273187 0.78 ACLY (0.49) DHODHACLYHDAC1
SCHEMBL2274953 0.76 ACLY (0.67) HDAC2DHODHACLYMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 HDAC2 276/4885DHODH 1469/4885ACLY 653/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.