SCHEMBL2274797

SCHEMBL2274797

O=C(Nc1cc(C2=COC(Cc3ccccc3)O2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.46
PKM P14618 2/20 0.46
KMT2A Q03164 2/20 0.46
MAPT P10636 2/20 0.46
GRIK1 P39086 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
ACLY P53396 3/20 0.46
LTC4S Q16873 1/20 0.44
DHODH Q02127 1/20 0.43
MCL1 Q07820 1/20 0.41
BCL2A1 Q16548 1/20 0.41
HDAC1 Q13547 3/20 0.40
HDAC2 Q92769 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
SUCNR1 Q9BXA5 1/20 0.39
KDM4D Q6B0I6 1/20 0.39
KDM4C Q9H3R0 1/20 0.39
HDAC3 O15379 1/20 0.39
PLK1 P53350 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272855 0.93 HDAC2 (0.43) MEN1PKMKMT2AMAPTGRIK1
SCHEMBL2272946 0.91 ACLY (0.48) KMT2AACLYDHODHHDAC2NPC1
SCHEMBL2272547 0.91 ACLY (0.40) ACLYDHODHMCL1NPC1RAB9A
SCHEMBL2274231 0.86 ACLY (0.39) MEN1KMT2AMAPTTDP1ACLY
SCHEMBL2274014 0.84 HDAC1 (0.50) MEN1PKMKMT2AMAPTTDP1
SCHEMBL2270861 0.83 TRPM2 (0.48) MEN1PKMKMT2AMAPTNPC1
SCHEMBL2273187 0.82 ACLY (0.49) ACLYDHODHMCL1HDAC1SUCNR1
SCHEMBL2276203 0.82 CYP1A2 (0.41) MEN1KMT2AMAPTHDAC1HDAC2
SCHEMBL2270239 0.81 PYGM (0.46) MEN1PKMKMT2AMAPTGRIK1
SCHEMBL2276077 0.80 PRSS12 (0.43) MEN1PKMKMT2AMAPTGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885PKM 2367/4885KMT2A 1669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.