SCHEMBL2274887

SCHEMBL2274887

O=C(Nc1cc(/C=C/c2ccc3c(c2)OCCO3)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.57
RAB9A P51151 7/20 0.57
NPC1 O15118 6/20 0.57
SMN1; SMN2 Q16637 7/20 0.55
ALDH1A1 P00352 4/20 0.55
KDM4E B2RXH2 3/20 0.55
NPSR1 Q6W5P4 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
HPGD P15428 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
TP53 P04637 2/20 0.53
THRB P10828 1/20 0.53
PKM P14618 2/20 0.50
GRIK1 P39086 1/20 0.50
CA12 O43570 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
NFKB1 P19838 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274903 1.00 MAPT (0.57) MAPTRAB9ANPC1SMN1; SMN2ALDH1A1
SCHEMBL2276083 0.93 CA12 (0.58) MAPTRAB9ANPC1SMN1; SMN2ALDH1A1
SCHEMBL2276071 0.93 CA12 (0.58) MAPTRAB9ANPC1SMN1; SMN2ALDH1A1
SCHEMBL2271243 0.84 ADCY1 (0.61) MAPTRAB9ANPC1SMN1; SMN2ALDH1A1
SCHEMBL2276651 0.84 PKM (0.62) MAPTTDP1MEN1KMT2APKM
SCHEMBL2276655 0.84 PKM (0.62) MAPTTDP1MEN1KMT2APKM
SCHEMBL2271438 0.82 NPC1 (0.57) MAPTRAB9ANPC1SMN1; SMN2ALDH1A1
SCHEMBL2270230 0.80 KMT2A (0.57) MAPTRAB9ANPC1ALDH1A1TDP1
SCHEMBL2270237 0.80 KMT2A (0.57) MAPTRAB9ANPC1ALDH1A1TDP1
SCHEMBL2270271 0.80 PKM (0.54) MAPTTDP1MEN1KMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MAPT 4824/4885RAB9A 2238/4885NPC1 4836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.