SCHEMBL2275540

SCHEMBL2275540

O=C(C=Cc1ccc([N+](=O)[O-])cc1)Nc1cc(Oc2ccccc2)ccc1C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM2 O94759 2/20 0.58
KMT2A Q03164 7/20 0.55
CYP2C9 P11712 2/20 0.55
CYP3A4 P08684 1/20 0.55
RAB9A P51151 5/20 0.54
NPC1 O15118 4/20 0.54
TDP1 Q9NUW8 1/20 0.54
MAPT P10636 7/20 0.54
SMN1; SMN2 Q16637 5/20 0.54
MEN1 O00255 5/20 0.54
TRPA1 O75762 3/20 0.54
KDM4E B2RXH2 2/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
MAPK1 P28482 2/20 0.49
TP53 P04637 1/20 0.49
CYP2C19 P33261 1/20 0.49
FFAR1 O14842 1/20 0.49
LTB4R Q15722 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275533 1.00 TRPM2 (0.58) TRPM2KMT2ACYP2C9CYP3A4RAB9A
SCHEMBL2276495 0.90 ALDH1A1 (0.61) TRPM2KMT2ARAB9ANPC1TDP1
SCHEMBL2276494 0.90 ALDH1A1 (0.61) TRPM2KMT2ARAB9ANPC1TDP1
SCHEMBL2270176 0.88 TRPA1 (0.60) TRPM2KMT2ACYP2C9CYP3A4RAB9A
SCHEMBL2270181 0.88 TRPA1 (0.60) TRPM2KMT2ACYP2C9CYP3A4RAB9A
SCHEMBL2278133 0.86 TRPA1 (0.62) TRPM2KMT2ACYP2C9CYP3A4RAB9A
SCHEMBL2278127 0.86 TRPA1 (0.62) TRPM2KMT2ACYP2C9CYP3A4RAB9A
SCHEMBL2278165 0.85 TRPA1 (0.68) TRPM2KMT2ACYP2C9CYP3A4RAB9A
SCHEMBL2278170 0.85 TRPA1 (0.68) TRPM2KMT2ACYP2C9CYP3A4RAB9A
SCHEMBL2273176 0.84 TRPM2 (0.77) TRPM2KMT2ACYP2C9CYP3A4RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 TRPM2 3539/4885KMT2A 1669/4885CYP2C9 841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.