SCHEMBL2276495

SCHEMBL2276495

O=C(C=Cc1cccc([N+](=O)[O-])c1)Nc1cc(Oc2ccccc2)ccc1C(=O)O

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.61
HTT P42858 2/20 0.61
MAPT P10636 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
TRPV1 Q8NER1 5/20 0.59
TRPM2 O94759 1/20 0.59
SMN1; SMN2 Q16637 3/20 0.58
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276494 1.00 ALDH1A1 (0.61) ALDH1A1HTTMAPTTDP1TRPV1
SCHEMBL2275533 0.90 TRPM2 (0.58) ALDH1A1MAPTTDP1TRPM2SMN1; SMN2
SCHEMBL2275540 0.90 TRPM2 (0.58) ALDH1A1MAPTTDP1TRPM2SMN1; SMN2
SCHEMBL14428476 0.89 TRPV1 (0.58) ALDH1A1HTTMAPTTRPV1SMN1; SMN2
SCHEMBL2270176 0.86 TRPA1 (0.60) ALDH1A1MAPTTRPM2SMN1; SMN2MEN1
SCHEMBL2270181 0.86 TRPA1 (0.60) ALDH1A1MAPTTRPM2SMN1; SMN2MEN1
SCHEMBL6791019 0.85 ALDH1A1 (0.80) ALDH1A1HTTMAPTTDP1TRPV1
SCHEMBL6791025 0.85 ALDH1A1 (0.80) ALDH1A1HTTMAPTTDP1TRPV1
SCHEMBL2272147 0.85 TRPM2 (0.77) ALDH1A1HTTMAPTTDP1TRPV1
SCHEMBL2272146 0.85 TRPM2 (0.77) ALDH1A1HTTMAPTTDP1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ALDH1A1 645/4885HTT 3716/4885MAPT 4824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.