SCHEMBL2276375

SCHEMBL2276375

CC(C)(C)OC(=O)c1ccc(Oc2ccccc2)cc1NC(=O)c1cccc(Br)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.49
MAPT P10636 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
CASP3 P42574 1/20 0.47
HTT P42858 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
AKR1C2 P52895 2/20 0.47
AKR1C1 Q04828 2/20 0.47
HDAC8 Q9BY41 3/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
ABL1 P00519 1/20 0.46
TSHR P16473 1/20 0.46
RIN1 Q13671 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
PYGM P11217 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275596 0.88 FABP1 (0.51) HDAC8HDAC1HDAC6KMT2AMEN1
SCHEMBL2269525 0.86 GRIK1 (0.66) GRIK1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL2274026 0.85 PGR (0.61) MAPTKMT2AMEN1TSHRPYGM
SCHEMBL2275426 0.85 GRM5 (0.46) HDAC8HDAC1HDAC6KMT2AMEN1
SCHEMBL2269139 0.85 CYP2C9 (0.47) MAPTCYP2C9CYP2C19HDAC8HDAC1
SCHEMBL2275425 0.84 NPC1 (0.43) HDAC8HDAC1HDAC6KMT2AMEN1
SCHEMBL2269667 0.84 F10 (0.53) MAPTHDAC8HDAC1HDAC6KMT2A
SCHEMBL2272788 0.83 NR1H4 (0.55) GRIK1MAPTAKR1C2AKR1C1KMT2A
SCHEMBL2269847 0.83 HDAC2 (0.52) HDAC1TDP1PGR
SCHEMBL2270366 0.81 STK39 (0.47) HDAC8HDAC1HDAC6KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 GRIK1 2029/4885MAPT 4824/4885CYP1A2 883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.