SCHEMBL2276665

SCHEMBL2276665

O=C(Nc1cc(-c2ccc(F)cc2F)ccc1C(=O)O)C1=COC(Cc2ccccc2)O1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
USP2 O75604 1/20 0.41
ALDH1A1 P00352 1/20 0.41
DHFR P00374 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
LMNA P02545 1/20 0.41
ALB P02768 1/20 0.41
HMGB1 P09429 1/20 0.41
HPGD P15428 1/20 0.41
CXCL12 P48061 1/20 0.41
KMT2A Q03164 1/20 0.41
HIF1A Q16665 1/20 0.41
SLC22A6 Q4U2R8 1/20 0.41
ACMSD Q8TDX5 1/20 0.41
HSD17B10 Q99714 1/20 0.41
LTB4R Q15722 3/20 0.40
LTB4R2 Q9NPC1 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273187 0.85 ACLY (0.49) ACLY
SCHEMBL2272547 0.84 ACLY (0.40) ALDH1A1HPGDNPC1PRSS12ACLY
SCHEMBL2277761 0.83 ACLY (0.44) HCAR2PRSS12ACLY
SCHEMBL2274220 0.80 ACLY (0.49) HCAR2ACLY
SCHEMBL2278113 0.80 NPC1 (0.39) MEN1ALDH1A1CA1HPGDKMT2A
SCHEMBL2272855 0.79 HDAC2 (0.43) KDM4EMEN1LMNAKMT2AHCAR2
SCHEMBL2275462 0.78 HDAC2 (0.48) KDM4EMEN1ALDH1A1HPGDKMT2A
SCHEMBL2267869 0.77 CYP2C9 (0.45) KMT2AMAPTPRSS12
SCHEMBL2270444 0.77 MEN1 (0.54) TTRKDM4EMEN1USP2ALDH1A1
SCHEMBL2274797 0.75 MEN1 (0.46) MEN1ALDH1A1HPGDKMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 TTR 4427/4885KDM4E 1257/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.