Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MYC | P01106 | 3/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715918 | 1.00 | NPC1 (0.71) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL29467270 | 0.98 | NPC1 (0.68) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL2492855 | 0.98 | NPC1 (0.68) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL28771676 | 0.93 | NPC1 (0.63) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL8048603 | 0.90 | ALDH1A1 (0.61) | NPC1PTPN1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL10607126 | 0.89 | NPC1 (0.62) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL28086833 | 0.84 | NPC1 (0.70) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL10684744 | 0.84 | NPC1 (0.65) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL605593 | 0.83 | NPC1 (1.00) | NPC1PTPN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL3808106 | 0.83 | ALDH1A1 (0.70) | NPC1ALDH1A1ALOX15SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154937-A1 | CHLORINE-RESISTANT POLYETHYLENE COMPOUND AND ARTICLES MADE THEREFROM | Fina Technology, Inc. (US) | 2017-04-19 | — | — | EP | claimed |
| WO-2015191721-A1 | CHLORINE-RESISTANT POLYETHYLENE COMPOUND AND ARTICLES MADE THEREFROM | FINA TECHNOLOGY, INC. (US) | 2015-12-17 | — | — | WO | claimed |
| US-8211914-B2 | Inhibitors of diacylglycerol acyltransferase | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-07-03 | — | — | US | claimed |
| CN-102245024-A | Inhibitors of diacylglycerol aclytransferase | VIA PHARMACEUTICALS INC | 2011-11-16 | — | — | CN | claimed |
| EP-2378878-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Via Pharmaceuticals, Inc. (US) | 2011-10-26 | — | — | EP | claimed |
| WO-2010077861-A1 | INHIBITORS OF DIACYLGLYCEROL ACLYTRANSFERASE | VIA PHARMACEUTICALS, INC (US) | 2010-07-08 | — | — | WO | claimed |
| US-20100152445-A1 | Inhibitors of Diacylglycerol Acyltransferase | MADRIGAL PHARMACEUTICALS, INC. | 2010-06-17 | — | — | US | claimed |
| JP-57095976-A | — | — | None | — | — | JP | disclosed |
| EP-4085056-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | Berg LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| EP-4077309-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-114671818-A | Compound and derivatizing reagent, and method for synthesizing compound | 学校法人东京理科大学 | 2022-06-28 | — | — | CN | disclosed |
| US-20220002255-A1 | UBE2K MODULATORS AND METHODS FOR THEIR USE | THLIVERIS, ANDREW T. | 2022-01-06 | — | — | US | disclosed |
| EP-0838457-A1 | NOVEL PYRIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS ACTIVE INGREDIENT | SS Pharmaceutical Co., Ltd. (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5710150-A | ARGININE VASOPRESSIN ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0716083-A1 | BENZAZEPINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND INTERMEDIATE FOR THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-4611016-A | ORGANIC POLYMERIC MATERIALS | CIBA-GEIGY CORP. (US) | 1986-09-09 | — | — | US | disclosed |
| JP-S5795976-A | PIPERIDINOPHENYLCARBOXYLIC ACID DERIVATIVE AND ITS PREPARATION | NISSAN CHEM IND LTD | 1982-06-15 | — | — | JP | disclosed |
| US-4325863-A | POLYMERS | SANDOZ LTD. (CH) | 1982-04-20 | — | — | US | disclosed |
| WO-1980001566-A1 | BENZOFURAN-2-ONIC OR INDOLIN-2-ONIC COMPOUNDS AS STABILIZERS OF POLYMERS | SANDOZ AG (CH) | 1980-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002255-A1 | UBE2K MODULATORS AND METHODS FOR THEIR USE | UBE2N, UBE2B, UBE2E1 | NPC1 1821/4885PTPN1 3299/4885L3MBTL1 4151/4885 |
| US-20100152445-A1 | Inhibitors of Diacylglycerol Acyltransferase | DGAT2, DGAT1, ACAT2 | NPC1 1345/4885PTPN1 3694/4885L3MBTL1 1674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.