Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.51 |
| ▸ | GUSB | P08236 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22792227 | 0.86 | HRH1 (0.48) | HTR2AHRH1ALDH1A1MAPTKDM4E | |
| SCHEMBL22792714 | 0.80 | KIT (0.43) | ADRB1HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL22792004 | 0.80 | ACHE (0.54) | ACHEALDH1A1MAPT | |
| SCHEMBL22792194 | 0.79 | TSHR (0.50) | ALDH1A1GAAMAPTHTTKDM4E | |
| SCHEMBL22792188 | 0.77 | BRAF (0.53) | — | |
| SCHEMBL22792292 | 0.77 | ALOX15 (0.44) | ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL22791987 | 0.76 | VNN1 (0.49) | ALDH1A1MAPTKDM4E | |
| SCHEMBL906005 | 0.73 | HTR2C (0.63) | ADRB1HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL22792355 | 0.73 | PTGS2 (0.44) | ALDH1A1MAPTHTT | |
| SCHEMBL905869 | 0.73 | CDK9 (0.50) | ADRB1HTR7HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252229-A2 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |