Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.62 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 8/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22806434 | 0.80 | ALDH1A1 (0.65) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL22806648 | 0.80 | HPGD (0.72) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL311714 | 0.80 | HPGD (0.76) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL1423180 | 0.77 | HPGD (0.67) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL312255 | 0.77 | AKR1C3 (1.00) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL2436664 | 0.77 | HPGD (0.67) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL30933461 | 0.76 | HPGD (0.75) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL8934509 | 0.75 | HPGD (0.64) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL9080220 | 0.75 | AKR1C3 (0.72) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 | |
| SCHEMBL4650047 | 0.75 | HPGD (1.00) | AKR1C3AKR1C2AKR1C1HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356162-A1 | Heterocyclic Compounds as Lipoxygenase Inhibitors | DR. REDDY'S INSTITUTE OF LIFE SCIENCES (IN) | 2022-11-10 | — | — | US | disclosed |
| WO-2020255156-A1 | HETEROCYCLIC COMPOUNDS AS LIPOXYGENASE INHIBITORS | DR REDDY'S INSTITUTE OF LIFE SCIENCES (IN) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020255156-A1 | HETEROCYCLIC COMPOUNDS AS LIPOXYGENASE INHIBITORS | DR REDDY'S INSTITUTE OF LIFE SCIENCES (IN) | 2020-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356162-A1 | Heterocyclic Compounds as Lipoxygenase Inhibitors | LTC4S, ALOX12, ALOX15B | AKR1C3 73/4885AKR1C2 152/4885AKR1C1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.