Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2570498 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL2289558 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL2289089 | 0.76 | KDM4E (0.39) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL6158884 | 0.75 | DRD2 (0.58) | CYP19A1DRD2HTR1DDRD3 | |
| SCHEMBL10847170 | 0.71 | HPGD (0.72) | STSHPGDHSD11B1 | |
| SCHEMBL31535308 | 0.70 | DRD4 (0.55) | STSCA2CA12CA1CYP19A1 | |
| SCHEMBL26371404 | 0.70 | DRD2 (0.57) | CYP19A1DRD2HTR1DDRD3 | |
| SCHEMBL30629196 | 0.69 | ALDH1A1 (0.62) | STSALDH1A1KDM4ECA2MAPT | |
| SCHEMBL19204644 | 0.68 | MEN1 (0.46) | STSALDH1A1KDM4ECA2MAPT | |
| SCHEMBL30301334 | 0.68 | HSD11B1 (0.51) | STSALDH1A1KDM4ECA2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963300-B1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| EP-1963300-B1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| US-7998541-B2 | Benzochromene derivatives for use in liquid crystal media and as therapeutic active substances | MERCK PATENT GMBH (DE) | 2011-08-16 | — | — | US | disclosed |
| US-7998541-B2 | Benzochromene derivatives for use in liquid crystal media and as therapeutic active substances | MERCK PATENT GMBH (DE) | 2011-08-16 | — | — | US | disclosed |
| US-7998541-B2 | Benzochromene derivatives for use in liquid crystal media and as therapeutic active substances | MERCK PATENT GMBH (DE) | 2011-08-16 | — | — | US | disclosed |
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | MERCK PATENT GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | MERCK PATENT GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | MERCK PATENT GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| EP-1963300-A1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | Merck Patent GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007079842-A1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007079842-A1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | LPO, SBDS, OCIAD1 | STS 1882/4885ALDH1A1 1625/4885KDM4E 4576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.