Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | CASP1 | P29466 | 2/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2570498 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL26767895 | 0.81 | KDM4E (0.63) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL2289089 | 0.81 | KDM4E (0.39) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL26778273 | 0.80 | KDM4E (0.65) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL2283588 | 0.78 | STS (0.47) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL26767899 | 0.75 | KDM4E (0.61) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL26778277 | 0.74 | KDM4E (0.63) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL3757463 | 0.73 | MAOA (1.00) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL30465069 | 0.73 | KDM4E (1.00) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL3768560 | 0.73 | KDM4E (1.00) | ALDH1A1KDM4EHPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963300-B1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| EP-1963300-B1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| WO-2007079840-A9 | BENZOCHROMENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-07-12 | — | — | WO | disclosed |
| EP-1963298-B1 | Benzochromene derivatives | MERCK PATENT GMBH (DE) | 2011-11-02 | — | — | EP | disclosed |
| US-7998541-B2 | Benzochromene derivatives for use in liquid crystal media and as therapeutic active substances | MERCK PATENT GMBH (DE) | 2011-08-16 | — | — | US | disclosed |
| US-7998541-B2 | Benzochromene derivatives for use in liquid crystal media and as therapeutic active substances | MERCK PATENT GMBH (DE) | 2011-08-16 | — | — | US | disclosed |
| US-7998541-B2 | Benzochromene derivatives for use in liquid crystal media and as therapeutic active substances | MERCK PATENT GMBH (DE) | 2011-08-16 | — | — | US | disclosed |
| US-7824745-B2 | Benzochromene derivatives | MERCK PATENT GMBH (DE) | 2010-11-02 | — | — | US | disclosed |
| US-7824745-B2 | Benzochromene derivatives | MERCK PATENT GMBH (DE) | 2010-11-02 | — | — | US | disclosed |
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | MERCK PATENT GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | MERCK PATENT GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | MERCK PATENT GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090023802-A1 | Benzochromene Derivatives | MERCK PATENT GMBH (DE) | 2009-01-22 | — | — | US | disclosed |
| US-20090023802-A1 | Benzochromene Derivatives | MERCK PATENT GMBH (DE) | 2009-01-22 | — | — | US | disclosed |
| WO-2007079840-A2 | BENZOCHROMENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007079842-A1 | BENZOCHROMENE DERIVATIVES FOR USE IN LIQUID CRYSTAL MEDIA AND AS THERAPEUTIC ACTIVE SUBSTANCES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247620-A1 | Benzochromene Derivatives for Use in Liquid Crystal Media and as Therapeutic Active Substances | LPO, SBDS, OCIAD1 | ALDH1A1 1625/4885KDM4E 4576/4885HPGD 824/4885 |
| US-20090023802-A1 | Benzochromene Derivatives | SBDS, CRY1, DDT | ALDH1A1 676/4885KDM4E 3570/4885HPGD 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.