Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289731 | 0.91 | MMP2 (0.63) | MMP2MMP7MMP14ALDH1A1FFAR1 | |
| Guanidine SCHEMBL8772768 | 0.86 | ALDH1A1 (0.69) | MMP2MMP7MMP14ALDH1A1FFAR1 | |
| Guanidine SCHEMBL2279843 | 0.84 | MMP2 (0.65) | MMP2MMP7MMP14FFAR1HSD11B1 | |
| Guanidine SCHEMBL2289728 | 0.83 | NPC1 (0.69) | MMP2MMP7MMP14ALDH1A1NPC1 | |
| SCHEMBL20914731 | 0.82 | ALDH1A1 (0.72) | MMP2MMP7MMP14ALDH1A1NPC1 | |
| Guanidine SCHEMBL8415495 | 0.79 | HSD11B1 (0.58) | MMP2MMP7MMP14ALDH1A1HSD11B1 | |
| SCHEMBL2286565 | 0.78 | ALDH1A1 (0.45) | MMP2MMP7MMP14ALDH1A1NPC1 | |
| SCHEMBL924405 | 0.76 | ALDH1A1 (0.69) | MMP2MMP7MMP14ALDH1A1FFAR1 | |
| SCHEMBL5679198 | 0.76 | MMP2 (0.63) | MMP2MMP7MMP14ALDH1A1NPC1 | |
| SCHEMBL10338418 | 0.74 | ALDH1A1 (0.67) | MMP2MMP7MMP14ALDH1A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H691-H | CONTAINING IMIDOTHIOESTER COMPOUND AND BASE PRECURSOR; HEAT RESISTANCE, STABILITY, ANTIFOGGING AGENT | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-03 | — | — | US | claimed |
| CN-111217946-B | Composition comprising a compound containing a vinyl group | 东京应化工业株式会社 | 2022-12-06 | — | — | CN | disclosed |
| US-11199776-B2 | Resin composition | TORAY INDUSTRIES, INC. (JP) | 2021-12-14 | — | — | US | disclosed |
| CN-111527139-B | Alkali proliferating agent and alkali-reactive resin composition containing the same | 日本化药株式会社 | 2021-08-17 | — | — | CN | disclosed |
| CN-111527139-A | Alkali proliferating agent and alkali-reactive resin composition containing the same | 日本化药株式会社 | 2020-08-11 | — | — | CN | disclosed |
| CN-111217946-A | Composition comprising a compound containing a vinyl group | 东京应化工业株式会社 | 2020-06-02 | — | — | CN | disclosed |
| WO-2019163981-A1 | BASE PROLIFERATING AGENT, AND BASE-REACTIVE RESIN COMPOSITION CONTAINING SAID BASE PROLIFERATING AGENT | 日本化薬株式会社 | 2019-08-29 | — | — | WO | disclosed |
| US-20190241716-A1 | RESIN COMPOSITION | TORAY INDUSTRIES, INC. (JP) | 2019-08-08 | — | — | US | disclosed |
| US-8877432-B2 | Method of forming resist pattern and resist composition | TOKYO OHKA KOGYO CO., LTD. (JP) | 2014-11-04 | — | — | US | disclosed |
| EP-2199856-B1 | Cationic radiation curable compositions | AGFA GRAPHICS NV (BE) | 2013-08-07 | — | — | EP | disclosed |
| EP-0228085-A2 | Light-sensitive material containing silver halide, reducing agent and polymerizable compound, and image-forming method employing the same | FUJI PHOTO FILM CO., LTD. (JP) | 1987-07-08 | — | — | EP | disclosed |
| EP-0228083-A2 | Light-sensitive material containing silver halide, reducing agent and polymerizable compound, and image-forming method employing the same | FUJI PHOTO FILM CO., LTD. (JP) | 1987-07-08 | — | — | EP | disclosed |
| EP-0224214-A2 | Light-sensitive microcapsule containing polymerizable compound and silver halide, and light-sensitive material employing the same | FUJI PHOTO FILM CO., LTD. (JP) | 1987-06-03 | — | — | EP | disclosed |
| EP-0219087-A2 | Light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| US-4637975-A | CATIONIC DYE | FUJI PHOTO FILM CO., LTD. (JP) | 1987-01-20 | — | — | US | disclosed |
| US-4629676-A | DRY PROCESSING | FUJI PHOTO FILM CO., LTD. (JP) | 1986-12-16 | — | — | US | disclosed |
| EP-0202490-A1 | Method for forming a polymer image and image recording material therefor | FUJI PHOTO FILM CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |
| EP-0200011-A1 | Heat-developable light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1986-11-05 | — | — | EP | disclosed |
| EP-0198356-A1 | Heat developable light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1986-10-22 | — | — | EP | disclosed |
| EP-0192272-A2 | Color light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1986-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190241716-A1 | RESIN COMPOSITION | SLC7A1, F12, SLCO2A1 | MMP2 2396/4885MMP7 3299/4885MMP14 4390/4885 |
| US-11199776-B2 | Resin composition | SLC7A1, F12, SLCO2A1 | MMP2 2396/4885MMP7 3299/4885MMP14 4390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.