Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CES2 | O00748 | 5/20 | 0.46 |
| ▸ | CES1 | P23141 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691083 | 0.84 | MAPT (0.67) | MAPTGAACES2CES1ALDH1A1 | |
| Benzil SCHEMBL3796381 | 0.82 | MAPT (0.64) | MAPTGAACES2CES1ALDH1A1 | |
| SCHEMBL2877065 | 0.78 | MAPT (0.58) | MAPTGAACES2CES1ALDH1A1 | |
| SCHEMBL1885621 | 0.77 | MAPT (0.60) | MAPTGAACES2CES1ALDH1A1 | |
| SCHEMBL14948957 | 0.77 | CES2 (0.68) | MAPTCES2CES1ALDH1A1HSD17B10 | |
| SCHEMBL29723321 | 0.76 | MAPT (0.59) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL2555043 | 0.76 | MAPT (0.59) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL21430959 | 0.75 | ALDH1A1 (0.58) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL2307166 | 0.74 | MAPT (0.57) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL28746 | 0.74 | MAPT (1.00) | MAPTGAAALDH1A1HSD17B10CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566018-B2 | Treatment of infectious disease | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2023-01-31 | — | — | US | disclosed |
| US-20210009563-A1 | TREATMENT OF INFECTIOUS DISEASE | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566018-B2 | Treatment of infectious disease | INMT, MAVS, EIF2AK2 | MAPT 3932/4885GAA 509/4885CES2 333/4885 |
| US-20210009563-A1 | TREATMENT OF INFECTIOUS DISEASE | MAVS, EIF2AK2, INMT | MAPT 3385/4885GAA 577/4885CES2 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.