Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21076611 | 0.87 | ESR1 (0.37) | NR3C2MAOAMAOBNISCHL3MBTL1 | |
| SCHEMBL18683654 | 0.87 | NR3C2 (0.46) | NR3C2TAAR1MAOAMAOBNISCH | |
| SCHEMBL18811782 | 0.80 | ESR1 (0.37) | ALDH1A1ESR1ESR2SLC6A2SLC6A4 | |
| SCHEMBL18763535 | 0.78 | LMNA (0.42) | ALDH1A1ESR1ESR2P2RX7SLC6A2 | |
| SCHEMBL12120613 | 0.78 | GABRA1 (0.33) | ESR1 | |
| SCHEMBL23758353 | 0.77 | CYP3A4 (0.36) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22600284 | 0.77 | TSHR (0.39) | ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19831132 | 0.77 | GPR55 (0.35) | ALDH1A1ESR1ESR2 | |
| SCHEMBL23758345 | 0.76 | ALDH1A1 (0.34) | ALDH1A1ESR1ESR2SLC6A2SLC6A4 | |
| SCHEMBL19998188 | 0.76 | ALDH1A1 (0.37) | ALDH1A1ESR1ESR2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10894777-B2 | TG2 inhibitor piperazine compounds and uses thereof | UNIVERSITY OF OTTAWA (CA) | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10894777-B2 | TG2 inhibitor piperazine compounds and uses thereof | TGM2, TGM1, TGM3 | NR3C2 4850/4885TAAR1 3612/4885MAOA 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.