Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.95 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.95 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.95 |
| ▸ | MAOA | P21397 | 1/20 | 0.95 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.95 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.95 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.95 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.61 |
| ▸ | PNMT | P11086 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amphetamine SCHEMBL4781164 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Dextroamphetamine SCHEMBL8859 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL13746679 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Levamfetamine SCHEMBL9673275 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL910141 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL13747801 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL15094242 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL1560962 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Levamfetamine SCHEMBL2636 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL8858 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117529665-A | Amphetamine carbamate compounds and methods | 诺芬药品公司 | 2024-02-06 | — | — | CN | disclosed |
| US-20200114014-A1 | Novel Alpha-Hydroxy Carboxylic Acid and Derivatives and Other GRAS-Based Amide and Imide Prodrugs of Amphetamine Compounds and Uses Thereof | THOTTATHIL JOHN K (US) | 2020-04-16 | — | — | US | disclosed |
| EP-3609482-A1 | NOVEL ALPHA-HYDROXY CARBOXYLIC ACID AND DERIVATIVES AND OTHER GRAS- BASED AMIDE AND IMIDE PRODRUGS OF AMPHETAMINE COMPOUNDS AND USES THEREOF | Thottathil, John K. (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018191219-A1 | NOVEL ALPHA-HYDROXY CARBOXYLIC ACID AND DERIVATIVES AND OTHER GRAS- BASED AMIDE AND IMIDE PRODRUGS OF AMPHETAMINE COMPOUNDS AND USES THEREOF | THOTTATHIL JOHN K (US) | 2018-10-18 | — | — | WO | disclosed |
| US-8487134-B2 | Process for the synthesis of amphetamine derivatives | ARCHIMICA, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110196173-A1 | Process for the Synthesis of Amphetamine Derivatives | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT | 2011-08-11 | — | — | US | disclosed |
| WO-2010042120-A1 | PROCESS FOR THE SYNTHESIS OF AMPHETAMINE DERIVATIVES | ARCHIMICA, INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| CN-100534983-C | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 2009-09-02 | — | — | CN | disclosed |
| CN-1328277-C | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2007-07-25 | — | — | CN | disclosed |
| CN-1819995-A | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 2006-08-16 | — | — | CN | disclosed |
| CN-1231468-C | Chemical compounds | GLAXO GROUP LTD (GB) | 2005-12-14 | — | — | CN | disclosed |
| CN-1483025-A | Chemical compounds | — | 2004-03-17 | — | — | CN | disclosed |
| US-6649604-B2 | Analgesics; antidiabetic agents; antiinflamamtory agents | AMGEN INC. | 2003-11-18 | — | — | US | disclosed |
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2003-04-17 | — | — | US | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| US-6096753-A | Substituted pyrimidinone and pyridone compounds and methods of use | AMGEN INC. (US) | 2000-08-01 | — | — | US | disclosed |
| CN-1246857-A | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200114014-A1 | Novel Alpha-Hydroxy Carboxylic Acid and Derivatives and Other GRAS-Based Amide and Imide Prodrugs of Amphetamine Compounds and Uses Thereof | CES2, HCAR2, HCAR1 | SLC6A2 32/4885SLC6A3 20/4885TAAR1 68/4885 |
| US-20110196173-A1 | Process for the Synthesis of Amphetamine Derivatives | GNPAT, DDT, NAAA | SLC6A2 25/4885SLC6A3 24/4885TAAR1 82/4885 |
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | IL6, IL1B, IL1A | SLC6A2 3402/4885SLC6A3 3246/4885TAAR1 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.