Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | VHL | P40337 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24421587 | 0.81 | THRB (0.39) | ALOX15MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27122864 | 0.73 | SIGMAR1 (0.32) | — | |
| SCHEMBL27117909 | 0.73 | SIGMAR1 (0.32) | — | |
| SCHEMBL24421581 | 0.72 | THRB (0.41) | ALOX15MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL23986739 | 0.71 | LMNA (0.41) | ALOX15MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL25515048 | 0.71 | NHERF1 (0.42) | MEN1KMT2A | |
| SCHEMBL27262174 | 0.70 | MEN1 (0.36) | ALOX15MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL16193397 | 0.70 | ALOX15 (0.41) | ALOX15MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL19116890 | 0.69 | HDAC8 (0.30) | — | |
| SCHEMBL25031950 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |