Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 10/20 | 0.39 |
| ▸ | ATXN2 | Q99700 | 10/20 | 0.39 |
| ▸ | GPR183 | P32249 | 5/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | C5 | P01031 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | MAP2 | P11137 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22911013 | 0.90 | ENPP2 (0.40) | ENPP2ATXN2PTGS2MEN1ABCC4 | |
| SCHEMBL16759925 | 0.90 | ENPP2 (0.40) | ENPP2ATXN2PTGS2MEN1ABCC4 | |
| SCHEMBL22911158 | 0.86 | ENPP2 (0.38) | ENPP2ATXN2GPR183CCNCCDK8 | |
| SCHEMBL22911068 | 0.86 | ENPP2 (0.55) | ENPP2ATXN2GPR183MEN1KMT2A | |
| SCHEMBL22910877 | 0.81 | GHSR (0.40) | — | |
| SCHEMBL22911171 | 0.80 | MGLL (0.37) | ENPP2ATXN2GPR183CCNCCDK8 | |
| SCHEMBL22911087 | 0.80 | ENPP2 (0.36) | ENPP2ATXN2KMT2A | |
| SCHEMBL22911082 | 0.79 | LMNA (0.34) | ENPP2ATXN2MAPT | |
| SCHEMBL22911064 | 0.79 | PAX8 (0.41) | — | |
| SCHEMBL22910986 | 0.79 | AKR1C3 (0.44) | ENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | HOFFMANN-LA ROCHE INC. (US) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | NPY1R, NPY2R, DECR1 | ENPP2 2448/4885ATXN2 1316/4885GPR183 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.