Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16774460 | 0.85 | CYP3A4 (0.43) | F2RCYP3A4SIGMAR1 | |
| SCHEMBL15373349 | 0.79 | TRPA1 (0.38) | TRPA1ATMMAPTLMNANPC1 | |
| SCHEMBL14028816 | 0.79 | MAPT (0.54) | ATMKDM4EMAPTLMNAMEN1 | |
| SCHEMBL29364590 | 0.79 | MAPT (0.54) | ATMKDM4EMAPTLMNAMEN1 | |
| SCHEMBL22914960 | 0.76 | TSHR (0.45) | KDM4EMAPTLMNAMEN1NPC1 | |
| SCHEMBL20489081 | 0.76 | G6PD (0.38) | KDM4EMAPTLMNAMEN1NPC1 | |
| SCHEMBL22914956 | 0.76 | LMNA (0.37) | KDM4EMAPTLMNAMEN1NPC1 | |
| SCHEMBL20539343 | 0.76 | ALDH1A1 (0.33) | ALDH1A1F2RCYP3A4 | |
| SCHEMBL20484689 | 0.76 | ALDH1A1 (0.50) | TRPA1ATMKDM4EMAPTMEN1 | |
| SCHEMBL27916853 | 0.76 | POLB (0.46) | KDM4EMAPTLMNAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398110-B2 | Second generation inhibitors of mitochondrial permeability transition pore with improved plasma stability | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2025-08-26 | — | — | US | disclosed |
| US-20220289690-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4003009-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | Oregon Health & Science University (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021016594-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021016594-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289690-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | TIMM13, MTCH2, AFG3L2 | TRPA1 1260/4885ATM 4141/4885KDM4E 4629/4885 |
| US-12398110-B2 | Second generation inhibitors of mitochondrial permeability transition pore with improved plasma stability | TIMM13, MTCH2, AFG3L2 | TRPA1 1260/4885ATM 4141/4885KDM4E 4629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.