Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GRM5 | P41594 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ME2 | P23368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18591763 | 0.89 | MAPT (0.47) | ALDH1A1MAPTHTTGAAALOX15 | |
| SCHEMBL18592219 | 0.89 | ALDH1A1 (0.48) | ALDH1A1GRM5MAPTHTTGAA | |
| SCHEMBL21026182 | 0.81 | ME2 (0.49) | ALDH1A1MAPTHTTGAAALOX15 | |
| SCHEMBL18591747 | 0.77 | DRD4 (0.41) | ALDH1A1MAPTGAAHSD17B10 | |
| SCHEMBL23664609 | 0.76 | SMN1; SMN2 (0.45) | ALDH1A1MAPTHTTGAAALOX15 | |
| SCHEMBL13959039 | 0.73 | LMNA (0.63) | ALDH1A1MAPTHTTSMN1; SMN2MAPK1 | |
| SCHEMBL13959027 | 0.73 | HSP90AA1 (0.60) | ALDH1A1MAPTHTTGAAALOX15 | |
| SCHEMBL12929946 | 0.72 | NCF1 (0.60) | ALDH1A1MAPTGAAKDM4EKMT2A | |
| SCHEMBL13959023 | 0.72 | RAB9A (0.61) | ALDH1A1MAPTHTTALOX15SMN1; SMN2 | |
| SCHEMBL27116715 | 0.71 | SMN1; SMN2 (0.45) | ALDH1A1MAPTHTTGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220267305-A1 | MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2022-08-25 | — | — | US | disclosed |
| US-20210040081-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas, Inc. | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040081-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ESR1, GPER1, ESR2 | ALDH1A1 1117/4885GRM5 479/4885MAPT 2535/4885 |
| US-20220267305-A1 | MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ADRM1, MDM2, ESR2 | ALDH1A1 2935/4885GRM5 1204/4885MAPT 2402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.