Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.33 |
| ▸ | NT5M | Q9NPB1 | 1/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 3/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886706 | 0.81 | ABL1 (0.33) | ABL1RIN1POLBRNASE1 | |
| SCHEMBL29674405 | 0.79 | ADORA3 (0.40) | ADORA3ADORA2AADORA2B | |
| SCHEMBL22983976 | 0.79 | ADORA3 (0.40) | ADORA3ADORA2AADORA2B | |
| SCHEMBL6893059 | 0.79 | ADORA3 (0.39) | NT5EADORA3ADORA1 | |
| SCHEMBL22577522 | 0.79 | ADK (0.34) | — | |
| SCHEMBL25512274 | 0.76 | POLB (0.42) | ABL1RIN1POLBRNASE1P2RY6 | |
| SCHEMBL17832132 | 0.75 | POLB (0.37) | ABL1RIN1POLBP2RY6P2RY14 | |
| SCHEMBL22992440 | 0.74 | ABL1 (0.42) | ABL1RIN1POLBADORA3ADORA1 | |
| SCHEMBL14066105 | 0.73 | ABL1 (0.33) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL22984030 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159922-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230159922-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| EP-4013428-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | Ionis Pharmaceuticals, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021030763-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2021-02-18 | — | — | WO | disclosed |