Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964015 | 0.79 | ALDH1A1 (0.50) | TP53MAPTACACBALDH1A1KMT2A | |
| SCHEMBL8276621 | 0.77 | TP53 (0.42) | TP53MAPTTHRBDDB1CRBN | |
| SCHEMBL27592520 | 0.76 | HRH3 (0.47) | TP53MAPTACACBDDB1CRBN | |
| SCHEMBL2299147 | 0.75 | CA1 (0.48) | MAPTTHRBALDH1A1RAB9AKMT2A | |
| SCHEMBL3125920 | 0.75 | ACHE (0.41) | MAPTALDH1A1NAAAKMT2AMEN1 | |
| SCHEMBL2091100 | 0.72 | NAAA (0.46) | TP53THRBDDB1CRBNALDH1A1 | |
| SCHEMBL2092643 | 0.71 | NAAA (0.47) | TP53MAPTTHRBDDB1CRBN | |
| SCHEMBL2302743 | 0.71 | SLC6A4 (0.52) | MAPTRAB9AKMT2AMEN1 | |
| SCHEMBL2302199 | 0.71 | EPHX2 (0.41) | NAAAKMT2AMEN1 | |
| SCHEMBL2298535 | 0.70 | KMT2A (0.40) | ACACBALDH1A1RAB9ANAAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |