Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18769860 | 0.89 | ADRB2 (0.62) | SIGMAR1ADRB2HTR2AHTR2CHTR2B | |
| N-Benzylamphetamine SCHEMBL2798189 | 0.82 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBMAPK1CYP1A2 | |
| N-Benzylamphetamine SCHEMBL2451256 | 0.82 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBMAPK1CYP1A2 | |
| N-Benzylamphetamine SCHEMBL2795222 | 0.82 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBMAPK1CYP1A2 | |
| SCHEMBL8587899 | 0.82 | LMNA (0.71) | SIGMAR1ADRB2HTR2AHTR2CHTR2B | |
| N-Benzylamphetamine SCHEMBL8085021 | 0.81 | SIGMAR1 (0.96) | SIGMAR1LMNAPOLBMAPK1CYP1A2 | |
| SCHEMBL24997843 | 0.80 | SIGMAR1 (0.79) | SIGMAR1ADRB2HTR2ALMNAPOLB | |
| SCHEMBL12767657 | 0.80 | HTR2A (0.62) | SIGMAR1ADRB2HTR2AHTR2CHTR2B | |
| SCHEMBL10023024 | 0.80 | HTR2A (0.62) | SIGMAR1ADRB2HTR2AHTR2CHTR2B | |
| SCHEMBL29602616 | 0.80 | HTR2A (0.62) | SIGMAR1ADRB2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | TRMT1, AARS1, GARS1 | SIGMAR1 2321/4885ADRB2 3712/4885HTR2A 3576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.