Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Carbazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.59 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.59 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.58 |
| ▸ | TOP1 known ✓ | P11387 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.93 |
| ▸ | GPR3 | P46089 | 2/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.93 |
| ▸ | AHR | P35869 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TNKS | O95271 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbazole SCHEMBL29401120 | 1.00 | ALDH1A1 (0.93) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL16540938 | 1.00 | ALDH1A1 (0.93) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL27985525 | 0.97 | ALDH1A1 (0.88) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL6470140 | 0.97 | ALDH1A1 (0.88) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL27801512 | 0.97 | ALDH1A1 (0.88) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL29627417 | 0.97 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL30761795 | 0.97 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL29355407 | 0.97 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL30209164 | 0.97 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL370524 | 0.97 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220380367-A1 | MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS | THE UNIVERSITY OF MONTANA | 2022-12-01 | — | — | US | disclosed |
| US-11420967-B2 | Modified carbazoles as therapeutic agents | UNIVERSITY OF WASHINGTON (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3807262-A1 | MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS | University of Washington (US) | 2021-04-21 | — | — | EP | disclosed |
| US-20210094949-A1 | MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS | THE UNIVERSITY OF MONTANA | 2021-04-01 | — | — | US | disclosed |
| CN-108767275-A | A kind of nitrogen-doped carbon oxygen reduction catalyst and its preparation method and application based on tetrazine ring polycarbazole | 湘潭大学 | 2018-11-06 | — | — | CN | disclosed |
| CN-104651000-A | Oil product smell removal agent | WANG PEIQIANG | 2015-05-27 | — | — | CN | disclosed |
| CN-104312615-A | Oil deodorant | QINGDAO RUNXIN WEIYE SCIENCE & TRADING CO LTD | 2015-01-28 | — | — | CN | disclosed |
| CN-102925197-A | Oil product decolorizing agent | LI YUXIANG | 2013-02-13 | — | — | CN | disclosed |
| CN-101475858-B | Efficient petroleum product deodorizing agent | LI YUXIANG | 2013-02-06 | — | — | CN | disclosed |
| CN-101475858-A | Efficient petroleum product deodouring agent | YUXIANG LI (CN) | 2009-07-08 | — | — | CN | disclosed |
| CN-101475829-A | Efficient diesel decoloring agent | YUXIANG LI (CN) | 2009-07-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220380367-A1 | MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS | TUBB3, TUBB1, TUBA1C | MEN1 3161/4885PARP1 479/4885ACHE 2809/4885 |
| US-20210094949-A1 | MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS | TUBB3, TUBB1, TUBA1C | MEN1 3161/4885PARP1 479/4885ACHE 2809/4885 |
| US-11420967-B2 | Modified carbazoles as therapeutic agents | TUBB3, TUBB1, TUBA1C | MEN1 3161/4885PARP1 479/4885ACHE 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.