Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Propofol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 0.71 |
| ▸ | GABRB1 known ✓ | P18505 | 5/20 | 0.71 |
| ▸ | GABRB2 known ✓ | P47870 | 3/20 | 0.71 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.71 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.71 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.71 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.71 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.71 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.71 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CA1 | P00915 | 2/20 | 0.71 |
| ▸ | CA2 | P00918 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | FAAH | O00519 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propofol SCHEMBL2414429 | 0.84 | GABRA1 (1.00) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL36245 | 0.84 | GABRA1 (1.00) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| SCHEMBL102131 | 0.82 | GPR35 (0.64) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL1033835 | 0.82 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL5036811 | 0.82 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL10968616 | 0.82 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL10968613 | 0.82 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL8935177 | 0.82 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL4088686 | 0.82 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 | |
| Propofol SCHEMBL5087474 | 0.82 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111432858-B | Drug infusion device, system and method | 埃皮森特RX股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-115243741-A | Drug infusion device, system and method | 埃皮辛特瑞柯斯公司 | 2022-10-25 | — | — | CN | disclosed |
| US-20210244870-A1 | MEDICATION INFUSION DEVICES, SYSTEMS, AND METHODS | EPICENTRX, INC. | 2021-08-12 | — | — | US | disclosed |
| US-20210178050-A1 | MEDICATION INFUSION DEVICES, SYSTEMS, AND METHODS | EPICENTRX, INC. | 2021-06-17 | — | — | US | disclosed |
| WO-2021119433-A1 | MEDICATION INFUSION DEVICES, SYSTEMS, AND METHODS | EPICENTRX, INC. (US) | 2021-06-17 | — | — | WO | disclosed |
| EP-3801678-A1 | MEDICATION INFUSION DEVICES, SYSTEMS, AND METHODS | EpicentRx, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |
| CN-111432858-A | Drug infusion device, system and method | 埃皮森特RX股份有限公司 | 2020-07-17 | — | — | CN | disclosed |